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Table 3 Multiple Ordinal Regressions of Perceived Clinical Utility of NIPT for Ethical Concerns

From: Obstetric professionals’ perceptions of non-invasive prenatal testing for Down syndrome: clinical usefulness compared with existing tests and ethical implications

  

Abortion would become more prevalent

Patients will have limited autonomy to have a baby with Down syndrome

NIPT can lead to discrimination against newborns with Down syndrome

Testing performed when physicians have inadequate knowledge of NIPT

Lack of prior consultation about how NIPT is provided and performed

Increase in women’s undertaking NIPT without careful informed choice

More pregnant women would undergo multiple screening tests

  

AORa (95%CI)

AORa (95%CI)

AORa (95%CI)

AORa (95%CI)

AORa (95%CI)

AORa (95%CI)

AORa (95%CI)

Comparison of NIPT with FTS

Easier comprehension of test result

Y

1.04 (0.68--1.58)

1.12 (0.72–1.73)

     

N

0.72 (0.45--1.14)

0.72 (0.44–1.16)

     

Earlier detection of chromosome abnormality

Y

1.62 (1.04--2.51)*

      

N

0.57 (0.34--0.97)*

      

Earlier consideration of termination of pregnancy

Y

      

1.19 (0.78--1.82)

N

      

1.45 (0.93--2.27)

Less maternal stress in case of termination of pregnancy

Y

      

0.94 (0.61--1.45)

N

      

1.64 (1.06--2.54)*

Comparisons of NIPT with IPD

Earlier detection of chromosome abnormality

Y

1.59 (1.02--2.48)*

1.10 (0.70--1.72)

0.81 (0.49--1.33)

    

N

0.56 (0.34--0.94)*

0.64 (0.38--1.08)

0.94 (0.53--1.69)

    

Easier comprehension of test result

Y

1.11 (0.72--1.72)

0.91 (0.58--1.42)

0.82 (0.49--1.37)

    

N

0.51 (0.33--0.79)**

0.69 (0.43--1.10)

0.89 (0.52--1.51)

    

Higher sensitivity

Y

0.98 (0.63–1.53)

1.37 (0.87--2.17)

0.92 (0.55--1.55)

    

N

0.59 (0.38--0.92)*

0.52 (0.32--0.84)**

0.75 (0.44--1.27)

    

Further psychological assurance for low-risk women

Y

   

0.63 (0.40--0.99)*

0.51 (0.31--0.82)**

0.48 (0.29--0.81)**

 

N

   

1.34 (0.79--2.28)

1.85 (1.07--3.19)*

2.16 (1.21--3.87)**

 

Earlier consideration of termination of pregnancy

Y

      

1.29 (0.82--2.05)

N

      

1.13 (0.70--1.85)

  1. Y = Yes, N = No, DK = Don’t Know (reference group)
  2. *p < .05; ** p < .01, *** p < .001
  3. aadjusted for demographics variables, including age, gender, religion, profession, highest education, place of work, years of experience
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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