Abortion would become more prevalent | Patients will have limited autonomy to have a baby with Down syndrome | NIPT can lead to discrimination against newborns with Down syndrome | Testing performed when physicians have inadequate knowledge of NIPT | Lack of prior consultation about how NIPT is provided and performed | Increase in women’s undertaking NIPT without careful informed choice | More pregnant women would undergo multiple screening tests | ||
---|---|---|---|---|---|---|---|---|
AORa (95%CI) | AORa (95%CI) | AORa (95%CI) | AORa (95%CI) | AORa (95%CI) | AORa (95%CI) | AORa (95%CI) | ||
Comparison of NIPT with FTS | ||||||||
Easier comprehension of test result | Y | 1.04 (0.68--1.58) | 1.12 (0.72–1.73) | |||||
N | 0.72 (0.45--1.14) | 0.72 (0.44–1.16) | ||||||
Earlier detection of chromosome abnormality | Y | 1.62 (1.04--2.51)* | ||||||
N | 0.57 (0.34--0.97)* | |||||||
Earlier consideration of termination of pregnancy | Y | 1.19 (0.78--1.82) | ||||||
N | 1.45 (0.93--2.27) | |||||||
Less maternal stress in case of termination of pregnancy | Y | 0.94 (0.61--1.45) | ||||||
N | 1.64 (1.06--2.54)* | |||||||
Comparisons of NIPT with IPD | ||||||||
Earlier detection of chromosome abnormality | Y | 1.59 (1.02--2.48)* | 1.10 (0.70--1.72) | 0.81 (0.49--1.33) | ||||
N | 0.56 (0.34--0.94)* | 0.64 (0.38--1.08) | 0.94 (0.53--1.69) | |||||
Easier comprehension of test result | Y | 1.11 (0.72--1.72) | 0.91 (0.58--1.42) | 0.82 (0.49--1.37) | ||||
N | 0.51 (0.33--0.79)** | 0.69 (0.43--1.10) | 0.89 (0.52--1.51) | |||||
Higher sensitivity | Y | 0.98 (0.63–1.53) | 1.37 (0.87--2.17) | 0.92 (0.55--1.55) | ||||
N | 0.59 (0.38--0.92)* | 0.52 (0.32--0.84)** | 0.75 (0.44--1.27) | |||||
Further psychological assurance for low-risk women | Y | 0.63 (0.40--0.99)* | 0.51 (0.31--0.82)** | 0.48 (0.29--0.81)** | ||||
N | 1.34 (0.79--2.28) | 1.85 (1.07--3.19)* | 2.16 (1.21--3.87)** | |||||
Earlier consideration of termination of pregnancy | Y | 1.29 (0.82--2.05) | ||||||
N | 1.13 (0.70--1.85) |