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Table 4 Association of vitamin D supplementation and pregnancy-induced hypertension (PIH) outcomes in clinical trials

From: The role of vitamin D in pre-eclampsia: a systematic review

Author, Location, Year

Study Design

Subjects

Intervention

Key Findings

Results

Olsen and Secher, Denmark, 1990 [91]

Randomized controlled clinical trial

5644 pregnant women

2500 IU vitamin D supplement versus no supplement at week 20 of pregnancy

↓ PE

31.5% reduction in the odds (p < 0.005)

Olsen et al., Europe, 2000 [98]

Randomized placebo controlled clinical trial

386 women who previously experienced PIH

2.7 g n-3 fatty acids/day given from 33 weeks until delivery vs olive oil placebo

↔ PIH recurrence risk

OR = 0.98

95% CI: 0.63–1.53