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Table 3 NICU outcomes of very preterm singletons by mode of conceptions

From: Morbidity and mortality among very preterm singletons following fertility treatment in Australia and New Zealand, a population cohort study

 

Number

Percent

OR (95% CI)

AOR (95% CI)a

Hyaline membrane disease

 Spontaneous conception

14574

71.9

Ref

Ref

 HO

154

72.0

1.00 (0.74–1.36)

0.87 (0.62–1.21)

 ART

724

76.9

1.30 (1.11–1.52)

1.18 (0.99–1.40)

 AI

38

72.1

0.93 (0.52–1.67)

0.75 (0.41–1.42)

Necrotizing enterocolitis

 Spontaneous conception

817

4.0

Ref

Ref

 HO

3

1.4

0.34 (0.11–1.04)

0.33 (0.10–1.05)

 ART

49

5.2

1.30 (0.97–1.75)

1.43 (1.04–1.97)

 AI

2

3.7

0.92 (0.22–3.80)

0.85 (0.20–3.60)

Intra ventricular haemorrhage

 Spontaneous conception

4327

23.1

Ref

Ref

 HO

53

26.0

1.17 (0.85–1.60)

1.23 (0.86–1.75)

 ART

229

25.6

1.14 (0.98–1.33)

1.20 (1.00–1.43)

 AI

12

23.1

0.99 (0.52–1.90)

1.21 (0.61–2.40)

Retinopathy of prematurity

 Spontaneous conception

3896

26.6

Ref

Ref

 HO

49

31.6

1.27 (0.91–1.79)

1.04 (0.70–1.52)

 ART

187

27.2

1.03 (0.87–1.22)

1.00 (0.82–1.24)

 AI and other

10

23.3

0.83 (0.41–1.70)

0.99 (0.44–2.17)

Major surgery

 Spontaneous conception

1642

8.1

Ref

Ref

 HO

23

10.7

1.37 (0.89–2.11)

1.27 (0.79–2.02)

 ART

122

12.9

1.70 (1.39–2.06)

1.71 (1.37–2.13)

 AI

6

11.1

1.43 (0.61–2.34)

1.00 (0.389–2.60)

Deaths

 Spontaneous conception

1852

9.0

Ref

Ref

 HO

20

9.3

1.02 (0.65–1.63)

0.67 (0.38–1.18)

 ART

98

10.3

1.15 (0.93–1.43)

1.11 (0.86–1.42)

 AI

9

16.7

2.01 (0.98–4.13)

2.10 (0.93–4.76)

  1. a Adjusted for maternal age, gestational age, ethnicity, previous pre term, previous prenatal death, maternal hypertension, antepartum haemorrhage, premature rupture of membranes and antenatal steroid
  2. Significant results are in bold