Morbidity and mortality among very preterm singletons following fertility treatment in Australia and New Zealand, a population cohort study

Table 2 Birth conditions of very preterm singletons by mode of conceptions

	Number	Percent	OR (95% CI)	AOR (95% CI)^a
Small for gestational age
Spontaneous conception	1833	8.9	Ref	Ref
HO	35	16.2	1.97 (1.37–2.84)	1.52 (1.02–2.67)
ART	102	10.7	1.22 (0.99–1.51)	1.09 (0.87–1.38)
AI	16	29.6	4.29 (2.39–7.71)	2.98 (1.53–5.81)
5 min APGAR (Mod/ severe depressed)
Spontaneous conception	3659	18.0	Ref	Ref
HO	35	16.2	0.88 (0.61–1.27)	0.78 (0.52–1.18)
ART	176	18.6	1.04 (0.88–1.23)	1.02 (0.85–1.24)
AI	10	18.5	1.04 (0.52–2.06)	1.07 (0.52–2.22)
Extreme Low birth weight (<1000 g)
Spontaneous conception	6676	32.5	Ref	Ref
HO	88	40.7	1.43 (1.09–1.87)	1.13 (0.72–1.79)
ART	351	36.8	1.21 (1.06–1.38)	1.11 (0.88–1.40)
AI	22	40.7	1.43 (0.83–2.46)	1.01 (0.43–2.42)
Intubation during resuscitation
Spontaneous conception	8405	41.0	Ref	Ref
HO	101	46.8	1.26 (0.97–1.65)	1.16 (0.84–1.60)
ART	440	46.3	1.24 (1.09–1.41)	1.11 (0.94–1.30)
AI	22	40.7	0.97 (0.57–1.70)	0.87 (0.46–1.64)
Congenital abnormalities
Spontaneous conception	1197	6.0	Ref	Ref
HO	10	4.9	0.80 (0.42–1.51)	0.80 (0.42–1.52)
ART	93	10.1	1.75 (1.40–2.19)	1.71 (1.36–2.16)
AI	9	16.7	3.12 (1.52–6.40)	3.01 (1.47–6.19)

^a Adjusted for maternal age, gestational age, ethnicity, previous pre term, previous prenatal death, maternal hypertension, antepartum haemorrhage, premature rupture of membranes and antenatal steroid
Significant results are in bold

ISSN: 1471-2393