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Table 3 First prenatal test, time of diagnosis and pregnancy outcome according to year of birth in cases with a common trisomy (T21, T18, T13) in cases with T21 and cases with T13/18

From: The impact of national prenatal screening on the time of diagnosis and outcome of pregnancies affected with common trisomies, a cohort study in the Northern Netherlands

 

Year of birth

 

2005–2006

2007–2012

Total

Trisomy 21

N = 81

N = 250

N = 331

First prenatal test*

 PNS1

28

35%

93

37%

121

37%

 PNS2

2

2%

82

33%

84

25%

 PND

11

14%

16

6%

27

27%

 No PNS or PND

40

49%

59

24%

99

30%

Time of diagnosis

 Postnatal

44

54%

134

54%

178

54%

 Prenatal < 24 weeks

35

43%

107

43%

142

43%

 Prenatal > = 24 weeks

2

2%

9

4%

11

3%

Pregnancy outcome

 Live birth

46

57%

139

56%

185

56%

 Fetal death

2

2%

20

8%

22

7%

 TOP

33

41%

91

36%

124

37%

Trisomy 13 and 18

N = 47

N = 125

N = 172

First prenatal test*

 PNS1

19

40%

66

53%

85

49%

 PNS2

2

4%

27

22%

29

17%

 PND

18

38%

21

17%

39

23%

 No PNS or PND

8

17%

11

9%

19

11%

Time of diagnosis*

 Postnatal

8

17%

16

13%

24

14%

 Prenatal < 24 weeks

29

62%

105

84%

134

78%

 Prenatal > = 24 weeks

10

21%

4

3%

14

8%

Pregnancy outcome

 Live birth

9

19%

16

13%

25

15%

 Fetal death

12

26%

19

15%

31

18%

 TOP

26

55%

90

72%

116

67%

  1. T21 trisomy 21, T18 trisomy 18, T13 trisomy 13, PNS1 prenatal screening in first trimester, PNS2 prenatal screening in second trimester, PND prenatal diagnosis, TOP termination of pregnancy
  2. *p < 0.05