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Table 2 Propensity Score Adjusted Drug Effects, and Importance of Each Component or Combined Outcome in Pregnant Women Exposed to Total AED or Valproate Only

From: Combining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model

  Component Outcomes Propensity Score Adjusted Drug Effects (β ± SE, P Value) Spearman Correlation with the Length of Hospital Stay during Delivery (95%CI, P Value)
Total AED Group BD 0.34 ± 0.16, P = 0.0356 0.08 (0.05 ~ 0.12, P < .0001)
ACNB 0.60 ± 0.15, P = 0.0001 0.08 (0.04 ~ 0.11, P < .0001)
PCOC 0.70 ± 0.11, P < .0001 0.24 (0.20 ~ 0.27, P < .0001)
LBW 0.10 ± 0.02, P < .0001 0.13 (0.09 ~ 0.16, P < .0001)
APO 0.24 ± 0.03, P < .0001 0.24 (0.20 ~ 0.27, P < .0001)
Valproate Subgroup BD 0.96 ± 0.41, P = 0.0196 0.17 (0.05 ~ 0.29, P = 0.0066)
ACNB 0.67 ± 0.43, P = 0.1223 0.02 (−0.10 ~ 0.15, P = 0.7135)
PCOC 0.99 ± 0.32, P = 0.0019 0.16 (0.03 ~ 0.28, P = 0.0122)
LBW 0.10 ± 0.06, P = 0.0856 0.04 (−0.09 ~ 0.16, P = 0.5640)
APO 0.32 ± 0.09, P = 0.0004 0.16 (0.03 ~ 0.28, P = 0.0121)
  1. Covariates include: mother’s epilepsy diagnosis, mother’s anxiety diagnosis, mother’s bipolar diagnosis, mother’s mental disorder diagnoses, mother’s mental disorder diagnoses, mother’s infection and parasitic diagnosis, mother's age, father's age, mother’s education level, father’s education level, mother’s total number of prenatal visits, mother’s parity, mother’s marital status, mother’s previous gestational diabetes, mother’s previous gestational hypertension, mother’s previous cesarean
  2. BD Birth defects, ACNB Abnormal condition of new born, PCOC Pregnancy and obstetrical complication, LBW Low birth weight, APO Adverse Perinatal and Pregnancy Outcome