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Table 3 The estimate and adjusted OR of logistic regression analysis on the training cohort

From: Subgroup identification of early preterm birth (ePTB): informing a future prospective enrichment clinical trial design

Parameter

Estimate

Adjusted OR (95% CI)

P value

Intercept

-3.7154

-

<.0001

Mothers’ Age (%)

  ≤ 24 Years

-

1.0 (1.0–1.0)

-

 25-29 Years

0.0129

1.013 (0.995, 1.032)

0.169

 30-34 Years

0.1221

1.130 (1.108, 1.152)

<.0001

  ≥ 35 Years

0.3034

1.354 (1.325, 1.385)

<.0001

Mothers’ Nativity (%)

 Born in U.S.

-

1.0 (1.0–1.0)

-

 Born Outside U.S. /Unknown/Not Stated

-0.1274

0.880 (0.863, 0.898)

<.0001

Mothers’ Race (%)

 White

-

1.0 (1.0–1.0)

-

 Black

0.5727

1.773 (1.743, 1.803)

<.0001

 American Indian/Alaskan Native/Asian or Pacific Islander

0.0917

1.096 (1.066, 1.127)

<.0001

Mothers’ Hispanic Origin (%)

 Non-Hispanic/Hispanic Origin Not Stated

-

1.0 (1.0–1.0)

-

 Hispanic

0.0323

1.033 (1.013, 1.053)

0.009

Marital Status (%)

 Married

-

1.0 (1.0–1.0)

-

 Unmarried

0.2819

1.326 (1.304, 1.347)

<.0001

Mothers’ Education (%)

  ≤ High School or GED/Unknown

-

1.0 (1.0–1.0)

-

 Associate/Some College Credit

-0.1725

0.842 (0.828, 0.856)

<.0001

  ≥ Bachelor's

-0.3382

0.713 (0.698, 0.729)

<.0001

 Missing

0.0031

1.003 (0.966, 1.042)

0.8727

Pre-pregnancy Smoking Status (%) a

 Nonsmoker

-

1.0 (1.0–1.0)

-

 Smoker/Unknown/Not Stated

0.1677

1.183 (1.160, 1.206)

<.0001

Pre-pregnancy BMI (%) a

 Under Weight-Normal ≤24.9

-

1.0 (1.0–1.0)

-

 Overweight 25.0-29.9

-0.0174

0.983 (0.966, 1.000)

0.0472

 Obesity ≥30.0/Unknown/Not Stated

0.1195

1.127 (1.109, 1.145)

<.0001

Pre-pregnancy Diabetes Status (%) a

 No/Unknown/Not Stated

-

1.0 (1.0–1.0)

-

 Yes

0.5741

1.776 (1.685, 1.871)

<.0001

Pre-pregnancy Hypertension Status (%) a

   

 No/Unknown/Not Stated

-

1.0 (1.0–1.0)

 

 Yes

0.6849

1.984 (1.913, 2.056)

<.0001

Previous Preterm Birth Status (%) a

 No/Unknown/Not Stated

-

1.0 (1.0–1.0)

-

 Yes

1.0999

3.004 (2.929, 3.081)

<.0001

Infertility Treatment Usage Status (%) a

 No/Unknown/Not Stated

-

1.0 (1.0–1.0)

-

 Yes

1.6299

5.103 (4.888, 5.328)

<.0001

Fertility Enhancing Drug Usage Status (%) a

 No/Not Applicable/Unknown/Not Stated

-

1.0 (1.0–1.0)

-

 Yes

-0.1988

0.820 (0.769, 0.873)

<.0001

Delivery Payment Source (%) a

 Medicaid

-

1.0 (1.0–1.0)

-

 Private Insurance

-0.0352

0.965 (0.948, 0.983)

<.0001

 Self-pay/Other/Unknown

0.0762

1.079 (1.054, 1.105)

<.0001

  1. a: For the following parameters after mothers’ education, missing observations were automatically excluded from the analysis, and the corresponding parameters were automatically set to 0 due to they are from the same subset