Impact of obstetric interventions on condition at birth in extremely preterm babies: evidence from a national cohort study

Table 3 The effect of antenatal steroids on delivery room death

			Partial course		Full course		P-value^a
		N	Effect	(95% CI)	Effect	(95% CI)
Confounding only models
	Baseline	1701	0.13	(0.10 – 0.18)	0.09	(0.07 – 0.12)	—
	Baseline + GA	1701	0.39	(0.27 – 0.56)	0.35	(0.25 – 0.50)	<0.001
	’Clinical’ model^b	1656	0.47	(0.32 – 0.70)	0.45	(0.30 – 0.67)	0.215
	Complete model^c	1656	0.47	(0.31 – 0.74)	0.37	0.23 – 0.58)	<0.001
Models with effect modification by mode of delivery^{b, c}
	Clinical model: vaginal delivery	1656	0.44	(0.29 – 0.67)	0.42	(0.28 – 0.63)	0.10
	Clinical model: caesarean delivery		0.72	(0.21 – 2.50)	1.63	(0.44 – 6.09)
	Complete model: vaginal delivery		0.34	(0.21 – 0.55)	0.41	(0.26 – 0.64)	0.083
	Complete model: caesarean delivery		0.93	(0.24 – 3.63)	2.06	(0.49 – 8.65)

Odds ratios of the effect of antenatal steroids on delivery room death in the complete population of babies born at 22–26 completed weeks of gestation in England in 2006 who were known to be alive at admission to hospital and at the start of labour monitoring or delivery to perform Caesarean section
^aLikelihood ratio test p-value, comparing current to next simplest model described
^bThe clinical model for delivery room death was adjusted for: gestational age, tocolysis, mode of delivery, NICU level at birth, in utero transfer, and presence of a spontaneous labour
^cThe complete models were adjusted for the same factors as the clinical models, plus: who the parents were counselled by, what choice was expressed for resuscitation, and whether a decision was made to not perform Caesarean section in the presence of fetal distress

ISSN: 1471-2393