Impact of obstetric interventions on condition at birth in extremely preterm babies: evidence from a national cohort study

Morgan, Andrei S.; Marlow, Neil; Draper, Elizabeth S.; Alfirević, Zarko; Hennessy, Enid M.; Costeloe, Kate

doi:10.1186/s12884-016-1154-y

Table 1 Characteristics of key variables for the different study populations used in the obstetric antecedents investigation

From: Impact of obstetric interventions on condition at birth in extremely preterm babies: evidence from a national cohort study

Variable		“Complete” population		‘Counselled’ population			“Steroids only” population
		N	%	N	%	P-value^a	N	%	P-value^b
Antenatal steroids		1701	—	1484	—	—	1213	—	—
	None	488	28.69	358	24.12	0.01	0	0.00	<0.01
	Partial	452	26.57	400	26.95		452	37.26
	Full	761	44.74	726	48.92		761	62.74
Tocolysis		1720	—	1495	—	—	1213	—	—
	No	1283	74.59	1085	72.58	0.21	807	66.53	<0.01
	Yes	437	25.41	410	27.42		406	33.47
Delivery mode		1717	—	1495	—	—	1213	—	—
	Vaginal	1361	79.27	1170	78.26	0.51	901	74.28	<0.01
	Caesarean	356	20.73	325	21.74		312	25.72
Gestational age		1722	—	1495	—	—	1213	—	—
	22 weeks	204	11.85	165	11.04	0.90	19	1.57	<0.01
	23 weeks	281	16.32	252	16.86		139	11.46
	24 weeks	366	21.25	322	21.54		303	24.98
	25 weeks	436	25.32	391	26.15		374	30.83
	26 weeks	435	25.26	365	24.41		378	31.16
Fetal sex		1719	—	1492	—	—	1213	—	—
	Female	804	46.77	699	46.85	0.99	586	48.31	0.43
	Male	915	53.23	793	53.15		627	51.69
HR >100 5 min after birth		1722	—	1495	—	—	1213	—	—
	No	600	34.84	505	33.78	0.55	274	22.59	<0.01
	Yes	1122	65.16	990	66.22		939	77.41
Delivery room death		1722	—	1495	—	—	1213	—	—
	No	1238	71.89	1078	72.11	0.92	1035	85.33	<0.01
	Yes	484	28.11	417	27.89		178	14.67
Counselled by...		1722	—	1495	—	—	1213	—	—
	No one/not counselled	227	13.18	0	0.00	<0.01	87	7.17	<0.01
	Junior obstetrician only	168	9.76	168	11.24		94	7.75
	Senior obstetrician only	165	9.58	165	11.04		96	7.91
	Paediatrician and junior obstetrician	418	24.27	418	27.96		353	29.10
	Paediatrician and senior obstetrician	744	43.21	744	49.77		583	48.06
Decision to not perform C/S		1158	—	1017	—	—	820	—	—
	No	807	69.69	666	65.49	0.04	571	69.63	1.00
	Yes	351	30.31	351	34.51		249	30.37
Resuscitation choice expressed		1235	—	1130	—	—	881	—	—
	No choice expressed	508	41.13	403	35.66	0.06	332	37.68	<0.01
	Full intensive care	391	31.66	391	34.60		346	39.27
	Withhold intensive care	45	3.64	45	3.98		9	1.02
	At paediatric discretion	291	23.56	291	25.75		194	22.02
Discussion about withholding care		1178	—	1048	—	—	816	—	—
	Not discussed	713	60.53	583	55.63	0.02	545	66.79	0.01
	Discussed	465	39.47	465	44.37		271	33.21

Characteristics of key variables from the EPICure 2 cohort study of births at 22–26 completed weeks of gestation in England in 2005. Mother-baby pairs were divided into three populations: the full population consisted of babies who were alive at admission to hospital and the commencement of labour monitoring or the decision to perform caesarean section (C/S). The two sub-populations studied in sensitivity analyses comprised mothers who received counselling, and those who received steroids
^aChi-squared test comparing distributions in the “counselled” and “full” populations
^bChi-squared test comparing distributions in the “steroids only” and “full” populations

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ISSN: 1471-2393

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