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Table 3 Predictive power of maternal serum CYFRA 21–1 levels in symptomatic women with preeclampsia (PE_state) and in asymptomatic women who later developed preeclampsia (PE_long)

From: The usefulness of CYFRA 21–1 to diagnose and predict preeclampsia: a nested case-control study

Predictor AUC 95 % CI Cut-off (ng/ml) Sensitivity Specificity p-value
For existing Preeclampsia (PE_state)
 CYFRA 21–1 level at visit:
  4 0.85 0.68–1 3.6 0.67 0.96 <0.001
  5 0.92 0.85–1 3.1 0.92 0.8 <0.001
  6 0.88 0.8–0.97 3.9 0.89 0.77 <0.001
For subsequent Preeclampsia (PE_long)
 CYFRA 21–1 level at visit:
  1 0.28 0.02–0.53 NDa ND ND 0.088
  2 0.51 0.29–0.74 2.5 0.44 0.7 0.909
  3 0.54 0.3–0.77 2.8 0.22 0.9 0.785
  4 0.71 0.51–0.9 2.1 0.88 0.53 0.037
  5 0.70 0.55–0.86 2.4 1 0.51 0.012
  6 0.69 0.48–0.9 2.7 1 0.34 0.074
 CYFRA 21–1 increase between visits:
  1 and 2 0.46 0.24–0.68 ND ND ND 0.724
  2 and 3 0.48 0.25–0.71 ND ND ND 0.857
  3 and 4 0.61 0.41–0.81 0.6 0.67 0.94 0.287
  4 and 5 0.66 0.51–0.82 0.6 0.83 0.76 0.042
  5 and 6 0.69 0.48–0.9 2.0 0.67 0.85 0.074
  1. aCut-off values, sensitivity, and specificity are not provided if the AUC is <0.5
  2. AUC area under the curve, 95 % CI 95 % confidence interval, CYFRA 21–1 Cytokeratin fragment 21–1, PE preeclampsia