Skip to main content

Table 1 Study outcome definitions

From: Maternal vitamin D supplementation during pregnancy and lactation to prevent acute respiratory infections in infancy in Dhaka, Bangladesh (MDARI trial): protocol for a prospective cohort study nested within a randomized controlled trial

Acute Respiratory Infection (ARI) Any upper respiratory tract infection or lower respiratory tract infection as defined below
Clinical Upper Respiratory Tract Infection (URTI) A new-onset illness consisting of at least two of the following clinical criteria at any time during a surveillance week:
• Caregiver-reported cough;
• Caregiver-reported rhinorrhea;
• Caregiver-reported nasal congestion;
• Measured temperature ≥37.5 °C (axillary)
confirmed with 2nd measurement
Clinical Lower Respiratory Tract Infection (LRTI) • Caregiver-reported cough AND/OR difficulty breathing during a surveillance week
AND
• Observed elevated respiratory rate (60 breaths per minute or greater for infant up to 59 days of age, or 50 breaths per minute or greater for infant 60 days of age or older) and/or lower chest wall in-drawing
OR
• Hospitalization with physician diagnosis of pneumonia or bronchiolitis
Microbiologically Confirmed URTI URTI that tests positive for at least one of influenza A, influenza B, respiratory syncytial virus, parainfluenza 1, 2, and 3, adenovirus, or human metapneumovirus
Microbiologically Confirmed LRTI LRTI that tests positive for at least one of influenza A, influenza B, respiratory syncytial virus, parainfluenza 1, 2, and 3, adenovirus, or human metapneumovirus