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Table 4 Maternal and fetal Doppler velocimetry, and main obstetric outcomes among controls and subjects with undifferentiated connective tissue disease (UCTD), major rheumatic diseases and no criteria for diagnosis

From: The impact of unrecognized autoimmune rheumatic diseases on the incidence of preeclampsia and fetal growth restriction: a longitudinal cohort study

  Controls n = 597 UCTD n = 131 Major rheumatic diseases n = 68 No criteria for diagnosis n = 150 p
mean (SD) mean (SD) mean (SD) mean (SD)  
I st trimester Uterine artery PI 1.16 (0.3) 1.64 (0.3) 1.80 (0.4) 1.37 (0.4) <.001
II nd trimester Uterine artery PI 0.87 (0.4) 1.29 (0.2) 1.33 (0.3) 1.00 (0.3) <.001
III rd trimester Umbilical Artery PI 0.89 (0.1) 0.95 (0.2) 1.03 (0.3) 0.95 (0.20) <.001
  N (%) N (%) N (%) N (%)  
Uterine artery bilateral notch
 Ist trimester 23 (3.8) 33 (25.2) 30 (44.1) 14 (9.3) <.001
 IInd trimester 14 (2.3) 15 (11.5) 18 (26.5) 9 (6) <.001
Umbilical artery PI >95° percentile 25 (4.2) 21 (16) 18 (26.5) 24 (16) <.001
Miscarriage 2 (0.3)    1 (0.6) 0.6
Stillbirth 1 (0.2)   1 (1.5)   0.3
Gestational diabetes 13 (2.2) 4 (3.1) 4 (5.8) 6 (4.0) 0.35
Small for gestational age 46 (7.7) 23 (17.5) 18 (26.5) 17 (11.3) <.001
Fetal growth restriction (FGR) 25 (4.2) 21 (16) 18 (26.5) 20 (13.3) <.001
Preeclampsia 19 (3.2) 18 (13.7) 15 (22.1) 9 (6) <.001
Preclampsia or FGR 36 (6) 30 (22.9) 20 (29.4) 22 (14.6) <.001
Delivery less than 34 weeks 17 (2.8) 6 (4.6) 5 (7.4) 4 (2.6) 0.2
Cesarean section 183 (30.6) 58 (44.3) 34 (50) 46 (30.6) 0.001
  1. SD standard deviation, PI pulsatility index
  2. p values obtained by one-way anova or chi-square test