• Unsure LMP and unwilling to have dating US | • Major Uterine Anomaly |
• ≥3 Miscarriages | • Cervical Suture |
• Major Foetal Anomaly/Abnormal Karyotype | • Knife cone biopsy |
• Essential Hypertension Treated Pre-pregnancy | • Ruptured membranes now |
• Mod-Severe Hypertension at booking (≥160/100 mmHg) | • Long term Steroids |
• Pre-pregnancy Diabetes | • Low-dose Aspirin |
• Renal Disease | • Calcium (>1 g/24 h) |
• Systemic Lupus Erythematosus | • Eicosapentaenoic acid (fish oil) |
• Anti-phospholipid Syndrome | • Vit. C ≥1000 mg & Vit. E ≥400 UI |
• Sickle Cell Disease | • Heparin/LMW Heparin |
• HIV or Hep B or Hep C positive |  |