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Table 2 Exclusion criteria of Preterm SAMBA validation phase – Brazilian cohort

From: Use of metabolomics for the identification and validation of clinical biomarkers for preterm birth: Preterm SAMBA

• Unsure LMP and unwilling to have dating US

• Major Uterine Anomaly

• ≥3 Miscarriages

• Cervical Suture

• Major Foetal Anomaly/Abnormal Karyotype

• Knife cone biopsy

• Essential Hypertension Treated Pre-pregnancy

• Ruptured membranes now

• Mod-Severe Hypertension at booking (≥160/100 mmHg)

• Long term Steroids

• Pre-pregnancy Diabetes

• Low-dose Aspirin

• Renal Disease

• Calcium (>1 g/24 h)

• Systemic Lupus Erythematosus

• Eicosapentaenoic acid (fish oil)

• Anti-phospholipid Syndrome

• Vit. C ≥1000 mg & Vit. E ≥400 UI

• Sickle Cell Disease

• Heparin/LMW Heparin

• HIV or Hep B or Hep C positive

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