Skip to main content
Fig. 1 | BMC Pregnancy and Childbirth

Fig. 1

From: Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fig. 1

Effects of statins on sFlt-1 secretion and mRNA expression of isoforms e15a and i13 expression in primary HUVECs. a Simvastatin (0, 1, 2, 5 μM) rosuvastatin (0, 1, 2, 5 μM) and pravastatin (0, 2, 5, 200 μM) reduce sFlt-1 secretion from primary HUVECs. b Inhibitory concentration of sFlt-1 at 50 % (IC50) for simvastatin, rosuvastatin and pravastatin was determined. c Pravastatin, simvastatin and rosuvastatin reduce sFlt-1 e15a mRNA expression from primary HUVECs. d Simvastatin reduces sFlt-1 i13 mRNA expression from HUVECs whilst pravastatin and rosuvastatin have no effect. Data represents n = 3 separate experiments and is expressed as mean ± SEM. Dark blue bars = control, light blue bars = statin treatments. b = p < 0.01, d = p < 0.0001

Back to article page

BMC Pregnancy and Childbirth

ISSN: 1471-2393

Contact us