The Breathing for Life Trial: a randomised controlled trial of fractional exhaled nitric oxide (FENO)-based management of asthma during pregnancy and its impact on perinatal outcomes and infant and childhood respiratory health

Table 1 FENO Algorithm cut-points and dose changes based on FENO measurement on NIOX MINO and results from the Asthma Control Questionnaire (ACQ)

Non-smokers NIOX MINO cut-points	Smokers NIOX MINO cut-points	Symptoms [ACQ]	ICS dose change	β₂-agonist dose change
>29 ppb	>22 ppb	N/A	↑ ICS x 1 step	No change
19–29	14–22	<=1.5	No change	No change
19–29	14–22	>1.5	No change	↑ LABA 1 step
<19	<14	<=1.5	↓ ICS x 1 step	No change
<19	<14	>1.5	↓ ICS x 1 step	↑ LABA 1 step

ISSN: 1471-2393