Vitamin D deficiency and supplementation in pregnancy in a multiethnic population-based cohort

Eggemoen, Åse R.; Falk, Ragnhild S.; Knutsen, Kirsten V.; Lagerløv, Per; Sletner, Line; Birkeland, Kåre I.; Jenum, Anne K.

doi:10.1186/s12884-016-0796-0

BMC Pregnancy and Childbirth

Table 3 Linear regression analysis with vitamin D [25(OH)D] at inclusion and gestational week 28 as dependant variables

From: Vitamin D deficiency and supplementation in pregnancy in a multiethnic population-based cohort

	At inclusion									At gestational week 28
	Univariate analysis					Multiple analysis				Univariate analysis					Multiple analysis
						n = 735, R² adj. = 0.46									n = 730, R² adj. = 0.24
Independent variable	R² adj.	B	95 % CI			B	95 % CI			R² adj.	B	95 % CI			B	95 % CI
			Lower	Upper			Lower	Upper				Lower	Upper			Lower	Upper
Gestational week at inclusion (<15 ref)	−0.001									0.01
ᅟ≥15		−0.56	−4.4	3.3							−6.4	−10	−2.3	**	−4.6	−8.3	−0.92	*
Age at inclusion	0.03	0.94	0.55	1.3	**	0.14	−0.21	0.49		0.03	1.1	0.64	1.5	**	0.70	0.26	1.1	**
Parity (para 0 ref)	0.02									0.01
ᅟPara1		−1.2	−5.4	3.1		0.24	−3.1	3.6			−2.8	−7.4	1.8		−4.4	−8.7	−0.22	*
ᅟPara ≥2		−11	−17	−6.3	**	−3.2	−7.6	1.3			−9.3	−15	−3.8	**	−5.4	−11	0.25
Geographic region (Western Europe ref)	0.38									0.16
ᅟSouth Asia		−37	−40	−33	**	−28	−33	−23	**		−26	−31	−21	**	−17	−23	−11	**
ᅟMiddle East		−34	−39	−30	**	−24	−29	−18	**		−21	−26	−15	**	−9.5	−16	−2.9	**
ᅟSub-Saharan Africa		−31	−37	−25	**	−20	−27	−13	**		−26	−34	−19	**	−12	−20	−3.1	**
ᅟEast Asia		−17	−24	−10	**	−11	−18	−3.9	**		−19	−28	−11	**	−11	−20	−1.6	*
ᅟOther		−13	−19	−6.4	**	−7.6	−14	−0.90	*		−9.0	−17	−1.3	*	−1.4	−9.6	6.9
Season (Summer ref)	0.03									0.01
ᅟWinter		−9.9	−14	−6.1	**	−5.2	−8.9	−1.4	**		−5.7	−9.8	−1.6	**	−1.3	−6.1	3.4
Geographic region*Season^a						−11	−16	−4.8	**						−15	−22	−7.4	**
Education level (>12 y ref)	0.11									0.08
ᅟ10-12 year		−14	−18	−10	**	−3.7	−7.1	−0.30	*		−11	−15	−6.8	**	−1.8	−6.1	2.5
ᅟ<10 year		−23	−28	−17	**	−5.2	−10	−0.31	*		−23	−29	−17	**	−8.6	−15	−2.5	**
Vitamin D supplements (≥10μg^b ref)	0.08									0.02
ᅟNo or <10 μg		−15	−19	−11	**	−11	−14	−7.7	**		−8.2	−13	−3.8	**	−9.8	−14	−5.8	**
Pre-pregnancy BMI (<25 kg/m²ref)	−0.001									−0.001
ᅟ≥25 kg/m²		−0.76	−4.7	3.2							−0.11	−4.4	4.2

^aThe effect of season on 25(OH)D differed by ethnicity: the interaction term is "1" for records with both non-Western and winter and "0" for Western and summer (ref)
^bIntake of ≥10 μg vitamin D daily past two weeks
Bold numbers indicate p < 0.05 (*p < 0.05, ** p < 0.01)

Back to article page

ISSN: 1471-2393

Contact us

Submission enquiries: bmcpregnancyandchildbirth@biomedcentral.com
General enquiries: ORSupport@springernature.com