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Table 6 Major types of sampling designs in human genetics and the types of genetic inferences that can be made (modified from [32])

From: The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes

Sampling design

Possible inferences

 

Heritability

Linkage

Association

Unrelated individuals

+

Triads (parents, one offspring)

+

+

Sibling pairs

+

+

+

Nuclear families

+

+

+

Extended pedigrees

+

+

+