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Table 2 Malformation prevalence at birth, stratified by anomaly groups before and after the establishment of prenatal screening, per 1000 newborns

From: Changes in detection of birth defects and perinatal mortality after introduction of prenatal ultrasound screening in the Kola Peninsula (North-West Russia): combination of two birth registries

Group of birth defect (ICD-10 codes)

1973-2000

 

2001-2011

 

p-value1

Number (N) of newborns: 23 822

Number (N) of newborns: 6626

 

N of BD

Prevalence2

N of BD

Prevalence2

 

Congenital malformations of the nervous system (Q00-Q07)

40

1.7 (1.2-2.2)

14

2.1 (1.0-3.2)

0.450

Congenital malformations of eye, ear, face and neck (Q10-Q18)

11

0.5 (0.2-0.7)

6

0.9 (0.2-1.6)

0.174

Congenital malformations of the circulatory system (Q20-Q28)

58

2.4 (1.8-3.1)

7

1.1 (0.3-1.8)

0.032

Congenital malformations of the respiratory system(Q30-Q34)

26

1.1 (0.7-1.5)

3

0.5 (0–1.0)

0.138

Cleft lip and cleft palate (Q35-Q37)

31

1.3 (0.8-1.8)

7

1.1 (0.3-1.8)

0.624

Congenital malformations of the digestive system (Q38-Q45)

29

1.2 (0.8-1.7)

7

1.1 (0.3-1.8)

0.743

Congenital malformations of genital organs (Q50-Q56)

86

3.6 (2.8-4.4)

26

3.9 (2.4-5.4)

0.696

Congenital malformations of the urinary system (Q60-Q64)

21

0.9 (0.5-1.3)

113

17.1 (14.0-20.2)

<0.0001

Congenital malformations and deformations of the musculoskeletal system (Q65-Q79)

323

13.5 (12.1-15.0)

63

9.5 (7.2-11.9)

0.010

Other congenital malformations, excluding multiple (Q80-Q89, excluding Q 89.7)

98

4.1 (3.3-4.9)

12

1.8 (0.8-2.8)

0.007

Chromosomal abnormalities (Q90-Q99)

17

0.7 (0.4-1.1)

5

0.8 (0.1-1.4)

0.807

Multiple congenital malformation, not classified

76

3.2 (2.5-3.9)

20

3.0 (1.7-4.4)

0.937

  1. 1 p-value for chi-squared test
  2. 2 95 % confidence intervals are presented in parentheses