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Table 2 Malformation prevalence at birth, stratified by anomaly groups before and after the establishment of prenatal screening, per 1000 newborns

From: Changes in detection of birth defects and perinatal mortality after introduction of prenatal ultrasound screening in the Kola Peninsula (North-West Russia): combination of two birth registries

Group of birth defect (ICD-10 codes) 1973-2000   2001-2011   p-value1
Number (N) of newborns: 23 822 Number (N) of newborns: 6626  
N of BD Prevalence2 N of BD Prevalence2  
Congenital malformations of the nervous system (Q00-Q07) 40 1.7 (1.2-2.2) 14 2.1 (1.0-3.2) 0.450
Congenital malformations of eye, ear, face and neck (Q10-Q18) 11 0.5 (0.2-0.7) 6 0.9 (0.2-1.6) 0.174
Congenital malformations of the circulatory system (Q20-Q28) 58 2.4 (1.8-3.1) 7 1.1 (0.3-1.8) 0.032
Congenital malformations of the respiratory system(Q30-Q34) 26 1.1 (0.7-1.5) 3 0.5 (0–1.0) 0.138
Cleft lip and cleft palate (Q35-Q37) 31 1.3 (0.8-1.8) 7 1.1 (0.3-1.8) 0.624
Congenital malformations of the digestive system (Q38-Q45) 29 1.2 (0.8-1.7) 7 1.1 (0.3-1.8) 0.743
Congenital malformations of genital organs (Q50-Q56) 86 3.6 (2.8-4.4) 26 3.9 (2.4-5.4) 0.696
Congenital malformations of the urinary system (Q60-Q64) 21 0.9 (0.5-1.3) 113 17.1 (14.0-20.2) <0.0001
Congenital malformations and deformations of the musculoskeletal system (Q65-Q79) 323 13.5 (12.1-15.0) 63 9.5 (7.2-11.9) 0.010
Other congenital malformations, excluding multiple (Q80-Q89, excluding Q 89.7) 98 4.1 (3.3-4.9) 12 1.8 (0.8-2.8) 0.007
Chromosomal abnormalities (Q90-Q99) 17 0.7 (0.4-1.1) 5 0.8 (0.1-1.4) 0.807
Multiple congenital malformation, not classified 76 3.2 (2.5-3.9) 20 3.0 (1.7-4.4) 0.937
  1. 1 p-value for chi-squared test
  2. 2 95 % confidence intervals are presented in parentheses