Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 7 Methylation at the leptin receptor locus by timing of psychiatric diagnosis among those not on antidepressant medication

From: Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth

Gene and locus Methylation (adjusted Beta) No History of Psychiatric Diagnosis and no Active Psychiatric Diagnosisb (n = 151) History of Psychiatric Diagnosis but no Active Psychiatric Diagnosis (n = 8) History of Psychiatric Diagnosis and Active Psychiatric Diagnosis (n = 13) p-value (Fisher’s exact test)
   57/151 (37.8 %) 2/8 (25.0 %) 10/13 (76.9 %)  
had SGA or IUGR had SGA or IUGR had SGA or IUGR
LEPRa <= Median 75 (49.7 %) 1 (12.5 %) 12 (92.3 %) 4.8 × 10−4
cg21655790 > Median 76 (50.3 %) 7 (87.5 %) 1 (7.7 %)
  1. aMethylation differs between these three categories (Fisher’s exact test p = 4.8 x 10−4). Three follow up tests (exact binomial tests that p = 0.5) revealed that those with active maternal psychiatric diagnoses are more likely to have below median placental methylation at LEPR/cg21655790 (FDR adjusted p = 0.01)
  2. bAs noted in Table 5, there were 2 people with no prior history of psychiatric diagnosis who had newly reported psychiatric diagnosis in pregnancy. Neither of these participants had LEPR/cg2165570 methylation data