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Table 6 Methylation at 6 candidate loci within strata defined by psychiatric and medication status

From: Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth

Gene and locus Methylation (adjusted Beta) No psychiatric diagnosis and no antidepressant (n = 159) Psychiatric diagnosis and no antidepressant (n = 13) Psychiatric diagnosis and antidepressant (n = 12) FDR adjusted p-value (Fisher’s exact test)
   59/159 (37.1 %) 10/13 (76.9 %) 9/12 (75.0 %)  
had SGA or IUGR had SGA or IUGR had SGA or IUGR
FKBP5 <= Median 79 (49.7 %) 4 (30.8 %) 8 (66.7 %) 3.7 × 10−01
cg08636224 > Median 80 (50.3 %) 9 (69.2 %) 4 (33.3 %)
RPE65 <= Median 85 (53.5 %) 4 (30.8 %) 6 (50.0 %) 3.7 × 10−01
cg11724759 > Median 74 (46.5 %) 9 (69.2 %) 6 (50.0 %)
LEPRa <= Median 76 (47.8 %) 12 (92.3 %) 5 (41.7 %) 2.9 × 10−02
cg21655790 > Median 83 (52.2 %) 1 (7.7 %) 7 (58.3 %)
LEPROTL1 <= Median 80 (50.3 %) 6 (46.2 %) 3 (25.0 %) 3.7 × 10−01
cg00177923 > Median 79 (49.7 %) 7 (53.9 %) 9 (75.0 %)
NFKBIZ <= Median 76 (47.8 %) 11 (84.6 %) 6 (50.0 %) 1.1 × 10−01
cg26284390 > Median 83 (52.2 %) 2 (15.4 %) 6 (50.0 %)
NFKBIZ <= Median 80 (50.3 %) 8 (61.5 %) 5 (41.7 %) 6.5 × 10−01
cg15006396 > Median 79 (49.7 %) 5 (38.5 %) 7 (58.3 %)
  1. aMethylation at LEPR/cg21655790 differs significantly between these three categories (Fisher’s exact test: FDR adjusted p = 0.029). Three follow up tests (exact binomial tests that p = 0.5) revealed that those with psychiatric diagnosis and no antidepressant medication are more likely to have below median placental methylation at LEPR/cg21655790 (FDR adjusted p = 0.01). NFKBIZ/cg26284390 has a very similar pattern of results as LEPR/cg21655790 but it misses significance in the Fisher’s exact test (FDR adjusted p = 0.107)