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Table 6 Methylation at 6 candidate loci within strata defined by psychiatric and medication status

From: Maternal psychiatric disease and epigenetic evidence suggest a common biology for poor fetal growth

Gene and locus

Methylation (adjusted Beta)

No psychiatric diagnosis and no antidepressant (n = 159)

Psychiatric diagnosis and no antidepressant (n = 13)

Psychiatric diagnosis and antidepressant (n = 12)

FDR adjusted p-value (Fisher’s exact test)

  

59/159 (37.1 %)

10/13 (76.9 %)

9/12 (75.0 %)

 

had SGA or IUGR

had SGA or IUGR

had SGA or IUGR

FKBP5

<= Median

79 (49.7 %)

4 (30.8 %)

8 (66.7 %)

3.7 × 10−01

cg08636224

> Median

80 (50.3 %)

9 (69.2 %)

4 (33.3 %)

RPE65

<= Median

85 (53.5 %)

4 (30.8 %)

6 (50.0 %)

3.7 × 10−01

cg11724759

> Median

74 (46.5 %)

9 (69.2 %)

6 (50.0 %)

LEPRa

<= Median

76 (47.8 %)

12 (92.3 %)

5 (41.7 %)

2.9 × 10−02

cg21655790

> Median

83 (52.2 %)

1 (7.7 %)

7 (58.3 %)

LEPROTL1

<= Median

80 (50.3 %)

6 (46.2 %)

3 (25.0 %)

3.7 × 10−01

cg00177923

> Median

79 (49.7 %)

7 (53.9 %)

9 (75.0 %)

NFKBIZ

<= Median

76 (47.8 %)

11 (84.6 %)

6 (50.0 %)

1.1 × 10−01

cg26284390

> Median

83 (52.2 %)

2 (15.4 %)

6 (50.0 %)

NFKBIZ

<= Median

80 (50.3 %)

8 (61.5 %)

5 (41.7 %)

6.5 × 10−01

cg15006396

> Median

79 (49.7 %)

5 (38.5 %)

7 (58.3 %)

  1. aMethylation at LEPR/cg21655790 differs significantly between these three categories (Fisher’s exact test: FDR adjusted p = 0.029). Three follow up tests (exact binomial tests that p = 0.5) revealed that those with psychiatric diagnosis and no antidepressant medication are more likely to have below median placental methylation at LEPR/cg21655790 (FDR adjusted p = 0.01). NFKBIZ/cg26284390 has a very similar pattern of results as LEPR/cg21655790 but it misses significance in the Fisher’s exact test (FDR adjusted p = 0.107)