Table 2 Characteristics of the randomized trials that have assessed tranexamic acid for preventing postpartum hemorrhage after vaginal delivery
Study [réf] | Country | Study design | Sample size | Study groups | Interventions | TXA Dosage/route | Primary outcome | Result | P value | Adverse effects |
|---|---|---|---|---|---|---|---|---|---|---|
Yang et al., (2001) [40] | China | Multicenter, randomized controlled study | N = 400 primiparas | N = 94 (experimental 1) | Infusion of TXA after delivery of the fetal shoulders in the first 2 groups and infusion of AMBA in the third | 1 g IV. | Measurement of blood loss 2 h after delivery, without details about the measurement method | 243.3 mL vs 242.9 mL vs 308.1 mL vs 314.8 mL | <0.01 | Nausea (n = 2) |
0.5 g IV | ||||||||||
N = 92 (experimental 2) | ||||||||||
N = 92 (experimental 3) | 0.5 g IV | |||||||||
N = 87 (no placebo) | placebo | |||||||||
Gungorkuk et al., (2013) [41] | Turkey | Prospective, single-center, double-blinded, randomized controlled study | N = 439 primiparas and multiparas | N = 220 (experimental) N = 219 (placebo) | Infusion of TXA at delivery of the anterior shoulder | 1 g IV for 5 min | Mean blood loss during the third and fourth stages of labor - from the end of delivery to 2 h postpartum- measured as (weight of material used – weight of materials before use)/1.05 | 261.5 mL vs 349.9 mL | <0.001 | Gastrointestinal side effects (35.9 %) |
No thromboembolic event |