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Table 5 Association of preterm birth and smoking with maternal cerebrovascular event (n = 1,848)

From: Preterm birth and future risk of maternal cardiovascular disease – is the association independent of smoking during pregnancy?

  Univariate Multivariate 1 Multivariate 2
  HR 95 % CI HR 95 % CI HR 95 % CI
Term birth Ref    Ref    Ref   
Any preterm birth 1.94 1.69 2.23 1.81 1.56 2.09 1.68 1.46 1.95
Preterm birth by severity          
Late preterm birth 1.68 1.39 2.03 1.58 1.31 1.91 1.49 1.23 1.80
Moderately preterm birth 2.20 1.64 2.97 2.07 1.54 2.78 1.90 1.41 2.56
Extremely preterm birth 2.45 1.90 3.16 2.32 1.75 3.07 2.13 1.61 2.82
Preterm birth by onset          
Spontaneous preterm birth 1.63 1.36 1.95 1.60 1.34 1.92 1.49 1.24 1.78
Indicated preterm birth 2.63 2.13 3.24 2.25 1.80 2.81 2.12 1.70 2.65
Preterm birth by number          
1 preterm birth 1.90 1.64 2.20 1.79 1.54 2.08 1.68 1.44 1.95
≥2 preterm births 2.43 1.58 3.73 1.99 1.28 3.07 1.76 1.14 2.73
Smokinga          
Never smoking during pregnancy Ref       Ref   
Smoking before last pregnancy 2.08 1.68 2.57     1.72 1.38 2.14
Smoking during last pregnancy 2.18 1.98 2.41     2.04 1.84 2.27
  1. Multivariate 1: Preterm birth adjusted for maternal age at delivery, country of birth, socioeconomic status, number of births, SGA, pregestational and gestational diabetes
  2. Multivariate 2: Variables in Multivariate 1 + maternal smoking during pregnancy
  3. a: Multivariate 2 adjusted for any preterm birth