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Table 4 Tissue AGAT and GAMT Expression

From: Maternal creatine homeostasis is altered during gestation in the spiny mouse: is this a metabolic adaptation to pregnancy?

 

Brain

Heart

Gastrocnemius muscle

 

Non-pregnant

Pregnant

Stats

Non-pregnant

Pregnant

Stats

Non-pregnant

Pregnant

Stats

AGAT mRNA

1.00 ± 0.06

0.48 ± 0.10

<0.01

1.00 ± 0.25

0.20 ± 0.02

<0.01

1.00 ± 0.11

0.40 ± 0.03

<0.01

AGAT Protein

1.00 ± 0.12

0.73 ± 0.18

NS

1.00 ± 0.26

0.46 ± 0.07

0.054

1.00 ± 0.45

1.23 ± 0.65

NS

GAMT mRNA

1.00 ± 0.15

0.23 ± 0.05

<0.001

1.00 ± 0.29

0.68 ± 0.05

NS

1.00 ± 0.13

0.78 ± 0.10

NS

GAMT Protein

1.00 ± 0.46

0.20 ± 0.07

0.05

1.00 ± 0.37

2.27 ± 0.35

<0.05

1.00 ± 0.42

0.77 ± 0.28

NS

  1. mRNA and protein expression of AGAT and GAMT in the brain, heart and skeletal muscle of non-pregnant and pregnant spiny mice at term. Data are expressed relative to the house keeping gene/protein. Values are means ± SEM; n = 6/group. Statistical analysis Students t-Test. Significance P ≤ 0.05.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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