Table 5 Regulation of lncRNAs on their associated mRNAs
PPROM vs. PTB | Strand* (lncRNA/mRNA) | lncRNA | mRNA | Gene name | Possible regulation mechanism |
|---|---|---|---|---|---|
lncRNA and mRNA with same expression pattern and located in the same strand | +/+ | ↑ | ↑ | TACC2 | LncRNAs have miRNA-binding sites and compete for the miRNAs of mRNA. |
NBPF10 | |||||
↓ | ↓ | PPP2R5C | |||
lncRNA and mRNA with opposite expression patterns and located in the same strand | +/+ | ↓ | ↑ | PAM | The product of gene is a bifunctional transcript, with one isoform as lncRNA and another as mRNA. |
↑ | ↓ | AQPEP | |||
PDE4B | |||||
lncRNA and mRNA with opposite expression patterns and located in opposite strands | −/+ | ↓ | ↑ | ADAMTS15 | LncRNA is the host to miRNAs which regulate mRNA through RNAi. |
EML4 | |||||
STAM | |||||
ncRNA and mRNA with same expression pattern and located in opposite strands | +/− | ↓ | ↓ | TATDN1 | LncRNA increases mRNA stability through masking miRNA site of mRNA. |