Figure 2

Metabolic pathways identified from differentially expressed lncRNAs in PPROM. Four groups of pathways (each group has up- and down-regulated) were characterized with KEGG functional analysis. Three p values, the EASE-score, Fisher-P value, and hypergeometric-P value, were integrated for the analysis. The bar plot shows the top enrichment score [−log10(Pvalue)] value of the significant enrichment pathway. If there were more than 10 pathways whose enrichment score is > 0.05, only the top 10 pathways are presented here. Three groups—AC vs. BD, up-regulation; CD vs. AB, up-regulation; and CD vs. AB, down-regulation—are shown here, with no down-regulation for AC vs. BD because few pathways could be identified by KEGG. The higher enrichment score indicates that more lncRNA molecules are involved in this pathway.