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Table 8 Impact of maternal hyperoxygenation for impaired fetal growth on stillbirth and perinatal mortality

From: Reducing stillbirths: interventions during labour

Source Location and Type of Study Intervention Stillbirths/Perinatal Outcomes
Reviews and meta-analyses
Say et al. 2003 [119] Italy, UK, South Africa.
Meta-analysis (Cochrane). 3 RCTs included (N = 94 women).
To assess the effects of maternal oxygen therapy (intervention) vs. management without additional oxygen (controls) in suspected impaired fetal growth on fetal growth and perinatal outcome. PMR: RR = 0.50 (95% CI: 0.32 – 0.81).
[15/46 vs. 31/48 in intervention and control groups, respectively].
Intervention studies
Battaglia et al. 1994 [120] Italy (Modena). Tertiary referral hospital (University of Modena).
Quasi-RCT. N = 38 patients with intrauterine growth retardation (N = 18 intervention group, N = 20 controls).
Compared the impact on fetal survival of bed rest plus humidified 55% oxygen at a rate of 8 l/min continuously (intervention) vs. bed rest (plus anti-hypertensive treatment, when necessary).
Ultrasound assessment of amniotic fluid volume was performed on alternate days, and the fetal abdominal circumference was evaluated weekly. Doppler analysis of fetal/maternal circulation was performed upon the patient's arrival at hospital, after 12 h, and thereafter on alternate days until parturition.
PMR: No deaths.