Source | Location and Type of Study | Intervention | Stillbirths/Perinatal Outcomes |
---|---|---|---|
Reviews and meta-analyses | |||
Say et al. 2003 [119] | Italy, UK, South Africa. Meta-analysis (Cochrane). 3 RCTs included (N = 94 women). | To assess the effects of maternal oxygen therapy (intervention) vs. management without additional oxygen (controls) in suspected impaired fetal growth on fetal growth and perinatal outcome. | PMR: RR = 0.50 (95% CI: 0.32 – 0.81). [15/46 vs. 31/48 in intervention and control groups, respectively]. |
Intervention studies | |||
Battaglia et al. 1994 [120] | Italy (Modena). Tertiary referral hospital (University of Modena). Quasi-RCT. N = 38 patients with intrauterine growth retardation (N = 18 intervention group, N = 20 controls). | Compared the impact on fetal survival of bed rest plus humidified 55% oxygen at a rate of 8 l/min continuously (intervention) vs. bed rest (plus anti-hypertensive treatment, when necessary). Ultrasound assessment of amniotic fluid volume was performed on alternate days, and the fetal abdominal circumference was evaluated weekly. Doppler analysis of fetal/maternal circulation was performed upon the patient's arrival at hospital, after 12 h, and thereafter on alternate days until parturition. | PMR: No deaths. |