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Table 18 Summary of evidence grading for all interventions prior to and during pregnancy to prevent stillbirth and perinatal mortality reviewed in this paper

From: Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy

 

Evidence of no or negative impact

(leave out of programs)

Uncertain evidence

(need for additional research before including in programs)

Some evidence

(may include in programs, but further evaluation is warranted)

Clear evidence

(merits inclusion in programs)

Calcium supplementation for pregnancy-induced hypertension

 

X1

  

Anti-hypertensives

 

X

  

Anti-platelet agents

 

X

  

Anti-oxidants

X

   

Heparin

   

X

(for certain conditions)

Management of intrahepatic cholestasis

  

X

 

Plasma exchange

 

X

  

Cervical cerclage

 

X

  

Anti-helminthics

  

X

 

Syphilis screening and treatment

  

X

 

Antibiotics for BV, asymptomatic bacteriuria, and GBS

 

X

  

Antibiotics for PROM/PPROM

 

X

  

Anti-malarials

  

X2

 

ITNs

   

X

PMTCT for HIV

X2

   

Periodontal care

 

X

  
  1. 1Possibly effective in some low-resource settings
  2. 2Maternal and infant benefit