From: Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy
Source | Location and Type of Study | Intervention | Stillbirths/Perinatal Outcomes |
---|---|---|---|
Reviews and meta-analyses | |||
Garner et al. 2006 [155] | Burkina Faso, Cameroon, Gambia, Nigeria, Uganda, Thailand, Kenya. Meta-analysis (Cochrane). 9 RCTs included. | Assessed 1) the impact of treating malaria with any anti-malarial drug (intervention #1) vs. no drug (control #1), and 2) preventing malaria with any anti-malarial drug (intervention #2) vs. no drug (control #2). | PMR (treatment): RR = 1.02 (95% CI: 0.73–1.43) [NS] in intervention group #1 vs. control group #1, respectively. PMR (prevention): RR = 0.73 (95% CI: 0.53–0.99) in intervention group #2 vs. control group #2, respectively. |
Intervention studies | |||
Hamer et al. 2007 [156] | Zambia (Ndola), urban setting. Cluster RCT. N = 456 HIV-positive mothers (N = 224 intervention group, N = 232 controls). | Compared 2 dosing schedules for malaria prevention: 1 treatment course of SP per month (intervention) vs. 1 course of SP per trimester (controls). | SBR: RR = 0.43 (95% CI: 0.1–2.2) [NS] [2/191 vs. 5/203 in intervention vs. control groups, respectively.] |
Observational studies | |||
Verhoeff et al. 1999 [202] | Malawi (Chikwawa district), rural setting. Prospective cohort study. N = 1523 women. | Assessed the impact of antenatal screening and treatment for malaria and anaemia. | SBR: 3.7% ENND (< 48 h postpartum): 1.7% |