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Table 2 Gene networks* overrepresented by differentially expressed genes associated with preterm delivery

From: Early pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study

Genes in Network

Score

Focus genes

Functions

14-3-3, AKAP12, Akt, ALK, Ap1, BIRC5, CaMKII, CD53, CD69, CDC25A, CYP2E1, E2f, FAM46A, FCER1A, FLT1, GATA2, HDC, Histone h3, HMGA2, IGHM, Mapk, NEFL, NFkB, P38 MAPK, PDGF BB, PRL, PROC, RGS7, SYNPO2, TAGLN, TIRAP, TNFRSF13B, TOP2A, Vegf, ZBTB10

49

24

Immune and Lymphatic System Development and Function, Tissue Morphology, Hematological System Development and Function

BMI1, CBS, CDCA5, CDKN2A, DHX8, DHX15, EEF1A1, EXOSC4, GAS7, GFM1, GPRC5A, HADHA, HOXA1, HOXA2, HOXA9, HOXA3 (includes EG:3200), HOXB2, HOXB9, HOXC5, ID4, KIF1B, MBNL1, MEG3 (includes EG:55384), MEIS2, MPHOSPH1, P4HA2, PBX1, PBXIP1, RCBTB2, RECQL4, retinoic acid, SKIV2L, TLX2, TMSB10, WSB1

24

14

Cellular Development, Nervous System Development and Function, Cell Cycle

AK2, androsterone, CCNI, CDK2, CKB, dihydrotestosterone, ECH1, GPD2, HIPK1, HSD17B6, KAP, LOC645619, MAK, ME1, MMP17, MS4A3, NCKAP1, NR6A1, RASAL2, SAMD4A, SEC22B, SLC16A7, SLC1A4, SLC45A3, SMURF1, SRGAP2, SVIL, TALDO1, thyroid hormone, TNF, WDR90, WT1, WTAP, YWHAG, ZNF7

22

13

Organ Development, Organ Morphology, Reproductive System Development and Function

ABP1, AKT1, amino acids, ANK3, CDKN3, CDKN1A, CHST13, EGF, HGF, HS3ST2, HS3ST5, HS3ST6, HS3ST3A1, HS3ST3B1, HS3ST4 (includes EG:9951), MYBL2, NEK4, NUSAP1, PCDHGA11, PCDHGC3, PELO, PRKAA1, RAMP1, SMP2A, SPG20, sulfotransferase, SULT1A2, SULT1A4, SULT1B1, SULT1C2, SULT1C4, SULT4A1, TERT, UST, ZNF622

22

13

Carbohydrate Metabolism, Amino Acid Metabolism, Post-Translational Modification

ABCB9, ACSBG1, ACSL3, ACSL4, ACSL5, ACSL6, ATP, butyric acid, C1QTNF2, CPA3, DDAH1, Ggt, GGT2, GGT3, GGT6, GGTL3, GGTL4, GGTLA1, GGTLA4, HOM-TES-103, IL13, JARID1A, KRAS, MTAP, NFYB, NR3C1, oleic acid, PITRM1, RERE, RPL41, SLC26A6, SLC7A5, ST8SIA4, TRIM45, ZNF610

19

12

Lipid Metabolism, Small Molecule Biochemistry, Molecular Transport

ACE2, AGT, BDKRB1, CCL2, CD177, CEBPB, CIITA, CRYBB2, CSF3, DARC, EMR1, ENPEP, EP300, HDAC1 (includes EG:3065), HLA-DOA, HLA-DOB, HLA-DQB1, HOPX, HP, IK, INMT, KNG1 (includes EG:3827), LPP, MCOLN2, MSH5, NAP1L1, PFKFB3, progesterone, PTGDS, RFXAP, RRM2, SALL1, SERBP1, TMEM176A, XPNPEP1

19

12

Cell-To-Cell Signaling and Interaction, Inflammatory Disease, Cardiovascular System Development and Function

  1. *The networks were generated through the use of Ingenuity Pathways Analysis (Ingenuity® Systems, http://www.ingenuity.com). Each gene identifier was mapped to its corresponding gene object in the Ingenuity Pathways Knowledge Base (IPKB). These genes were overlaid onto a global molecular network developed from information contained in the IPKB. Network enrichment is then assessed using a network score (negative log of p-values of Fisher tests). Focus genes (in bold) are genes identified in our list of differentially expressed genes. Networks shown here are those with network scores > 3.0.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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