Table 3 Reported adverse events in all included trials
From: Atosiban versus betamimetics in the treatment of preterm labour in Germany: an economic evaluation
Adverse event | Frequency (%) Atosiban | Frequency (%) Betamimetics | Relative risk and Confidence Intervals | p-value |
|---|---|---|---|---|
Tachycardia | 3.90% | 56.30% | RR = 0.07, 95% CI = 0.05, 0.1 | <0.001 |
Palpitation | 2.40% | 20.40% | RR = 0.12, 95% CI = 0.06, 0.22 | <0.001 |
Vomiting | 5.90% | 19.20% | RR = 0.27, 95% CI = 0.18, 0.4 | <0.001 |
Headache | 8.40% | 14.10% | RR = 0.59, 95% CI = 0.43, 0.8 | <0.001 |
Hyperglycaemia | 7.80% | 13.30% | RR = 0.57, 95% CI = 0.4, 0.89 | 0.001 |
Tremor | 0.80% | 12.20% | RR = 0.08, 95% CI = 0.04, 0.19 | <0.001 |
Nausea | 8.70% | 10.50% | RR = 0.79, 95% CI = 0.57, 1.08 | 0.135 |
Dyspnoea | 0.60% | 8.50% | RR = 0.09, 95% CI = 0.04, 0.23 | <0.001 |
Chest pain | 1.70% | 8.00% | RR = 0.18, 95% CI = 0.09, 0.38 | <0.001 |
Hypokalemia | 0.70% | 7.10% | RR = 0.13, 95% CI = 0.05, 0.36 | <0.001 |
Hypotension | 2.80% | 5.00% | RR = 0.6, 95% CI = 0.29, 1.11 | 0.1 |
Anxiety | 1.50% | 3.80% | RR = 0.43, 95% CI = 0.2, 0.91 | 0.027 |
Syncope | 0.60% | 0.50% | RR = 1.02, 95% CI = 0.17, 5.98 | 0.984 |
Pulmonary oedema | 0.30% | 0.50% | RR = 0.6, 95% CI = 0.08, 4.45 | 0.614 |
Myocardial ischemia | 0.00% | 0.30% | RR = 0.34, 95% CI = 0.01, 8.3 | 0.509 |
Foetal tachycardia | 2.90% | 21.10% | RR = 0.14, 95% CI = 0.08, 0.23 | <0.001 |