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Table 5 Range of estimated sample sizes

From: The INIS Study. International Neonatal Immunotherapy Study: non-specific intravenous immunoglobulin therapy for suspected or proven neonatal sepsis: an international, placebo controlled, multicentre randomised trial

Mortality or major morbidity in control group Mortality or major morbidity in IVIG group Relative risk reduction Total sample size required to detect difference with 95% confidence
    80% power 90% power
30% 26% 13% 4,052 5,392
30% 25% 17% 2,580 3,428
30% 20% 33% 626 824
25% 21% 16% 3,572 4,748
25% 20% 20% 2,266 3,006
25% 15% 40% 540 708
20% 16% 20% 2,994 3,972
20% 15% 25% 1,890 2,502
20% 12.5% 37.5% 810 1,066
15% 12% 20% 4,204 5,582
15% 10% 33% 1,450 1,914
12% 9% 25% 3,408 4,516
10% 7.5% 25% 4,166 5,524