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Table 2 Mortality in trials of IVIG for proven infection in neonates

From: The INIS Study. International Neonatal Immunotherapy Study: non-specific intravenous immunoglobulin therapy for suspected or proven neonatal sepsis: an international, placebo controlled, multicentre randomised trial

Study Exptl n/N Ctrl n/N Relative Risk (95% CI Fixed) Weight
Chen 1996 2/28 1/28 2.00 [0.19, 20.82] 3.8%
Erdem 1993 5/15 7/16 0.76 [0.31, 1.89] 25.4%
Haque 1988 1/21 4/23 0.27 [0.03, 2.26] 14.3%
Mancilla-Ramirez 1992 2/19 2/18 0.95 [0.15, 6.03] 7.7%
Samatha 1997 0/12 4/16 0.15 [0.01, 2.46] 14.6%
Sidiropoulos 1981 2/20 4/15 0.38 [0.08, 1.78] 17.2%
Weisman 1992 2/14 5/17 0.49 [0.11, 2.13] 17.0%
Total 14/129 27/133 0.55 [0.31, 0.98] 100%
  1. Review: IVIG in neonatal infection
  2. Comparison: IVIG vs placebo or no intervention for proven infection
  3. Outcome: Mortality from any cause