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Table 1 Mortality in trials of IVIG for suspected infection in neonates

From: The INIS Study. International Neonatal Immunotherapy Study: non-specific intravenous immunoglobulin therapy for suspected or proven neonatal sepsis: an international, placebo controlled, multicentre randomised trial

Study

Exptl n/N

Ctrl n/N

Relative Risk (95% CI Fixed)

Weight

Christensen 1991

0/11

0/11

not estimable

0

Erdem 1993

6/20

9/24

0.80 [0.34, 1.86]

22.0%

Haque 1988

1/30

6/30

0.17 [0.02, 1.30]

16.1%

Samatha 1997

5/30

8/30

0.62 [0.23, 1.69]

21.5%

Shenoi 1999

7/25

7/25

1.00 [0.41, 2.43]

18.8%

Sidiropoulos 1981

4/41

8/41

0.50 [0.16, 1.53]

21.5%

Total

23/157

38/161

0.63 [0.40, 1.00]

100%

  1. Review: IVIG in neonatal infection
  2. Comparison: IVIG vs placebo or no intervention for suspected infection
  3. Outcome: Mortality from any cause