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Table 1 Mortality in trials of IVIG for suspected infection in neonates

From: The INIS Study. International Neonatal Immunotherapy Study: non-specific intravenous immunoglobulin therapy for suspected or proven neonatal sepsis: an international, placebo controlled, multicentre randomised trial

Study Exptl n/N Ctrl n/N Relative Risk (95% CI Fixed) Weight
Christensen 1991 0/11 0/11 not estimable 0
Erdem 1993 6/20 9/24 0.80 [0.34, 1.86] 22.0%
Haque 1988 1/30 6/30 0.17 [0.02, 1.30] 16.1%
Samatha 1997 5/30 8/30 0.62 [0.23, 1.69] 21.5%
Shenoi 1999 7/25 7/25 1.00 [0.41, 2.43] 18.8%
Sidiropoulos 1981 4/41 8/41 0.50 [0.16, 1.53] 21.5%
Total 23/157 38/161 0.63 [0.40, 1.00] 100%
  1. Review: IVIG in neonatal infection
  2. Comparison: IVIG vs placebo or no intervention for suspected infection
  3. Outcome: Mortality from any cause