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Table 1 Emax, pD2 and intrinsic activity (IA) for the different ADRB2 or ADRB3 agonists presented in this paper

From: Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?

Compounds

Emax

pD2

IA

Isoprenaline

58% ± 9%

7.32 ± 0.62

100% (ref)

Salbutamol

27% ± 6%

6.0 ± 0.48

48% ± 7%

Ritodrine

62% ± 5%

7.26 ± 0.48

107% ± 6%

BRL 37344

60% ± 4%

7.64 ± 0.53

103% ± 4%

SR59119

52% ± 7%

5.65 ± 0.14

90% ± 7%

  1. Emax is expressed as a percentage of inhibition compared with initial amplitude of the contractions. The intrinsic activity (%IA) relative to the maximal effect of (-)-isoproterenol indicate the inhibition of the initial amplitude of spontaneous contractions.