Table 2 Adenylyl cyclase (ADCY) isoforms
From: Cyclic AMP signalling pathways in the regulation of uterine relaxation
Sub-family | Mode of regulation | Member | Chromosomal localization | Referen ces |
|---|---|---|---|---|
1 | Activated by calcium, Gαs, PRKA inhibited by Gαi/o and Gβγ | ADCY1 | 7p12 | Villacres et al. (1993) [54] |
ADCY3 | 5p15 | Diel et al. (2006) [55] | ||
ADCY8 | 2p22-24 | Steiner et al. (2006) [56] | ||
2 | Activated by Gαs and Gβγ | ADCY2 | 14q11.2 | Nguyen & Watts (2006) [57] |
ADCY4 | 3q13.2-q21 | Wang & Burns (2006) [58] | ||
ADCY7 | 12q12-13 | Guzman et al. (2005) [59] | ||
3 | Activated by Gαs, Inhibited by Gαi/o, Gβγ calcium, PRKA | ADCY5 | 16q12-13 | Iwami et al. (1995) [60] |
ADCY6 | 8q24 | Chen et al. (1997) [61] | ||
4 | Activated by Gαs | ADCY9 | 16p13 | Hacker et al. (1998) [62] |