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Table 4 Single versus double layer closure of the uterus

From: The CORONIS Trial. International study of caesarean section surgical techniques: a randomised fractional, factorial trial

Study n Infection Blood loss Health service use Other outcomes
   Outcome Result Outcome Result Outcome Result Outcome Result
Cochrane review 15 1,006 Endometritis (n = 784) (RR) 1.22 (0.91–1.63) Transfusion (n = 906) (RR) 0.80 (0.34–1.92) Operating time (Mean) 43.8 v 47.5 min Moderate or major deformity of 0.19 (0.06–0.60)
     Extra haemostatic sutures (n = 906) (RR) 0.93 (0.79–1.08)    scar on radiography (n = 100) (RR)  
     >8% drop in haematocrit (n = 906) (RR) 1.09 (0.86–1.38)     
Heidenreich 17 125 Post-operative fever 4.8% v. 7.2% Transfusion 3.8% v. 3.2%    Scar thickness by US (8–10 days after surgery) 0.72 v. 0.82 cm
Sood 18 208 Febrile morbidity (RR) 0.50 (0.27–0.94) Intraoperative blood loss (Mean) 600 v. 629.6 ml Operating time (Mean)
Hospital stay (Mean)
31.3 v. 33.1 min
6.67 v. 7.19 days
Pain (VAS Score) (Mean) 2.91 v. 3.05
   Endometritis (RR) 0.44 (0.20–0.95) Additional suture (RR) 1.36 (0.85–2.17)     
   Wound infection (RR) 0.46 (0.15–1.45)