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Table 2 Estimate of the effect of the eNOS Glu298Asp polymorphism on pre-eclampsia risk in the current case-control study stratified by ethnic group.

From: Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis

Model of inheritance Unadjusted OR (95%CI) P Adjusted OR* (95%CI) P
Additive
Asp/Asp vs Glu/Glu
All women 0.63 (0.23 – 1.72) 0.37 0.69 (0.25 – 1.92) 0.47
Caucasians 0.89 (0.30 – 2.59) 0.83 0.86 (0.29 – 2.52) 0.79
Afro-Caribbean N.A   N.A  
Asians N.A   N.A  
Glu/Asp vs Glu/Glu
  0.64 (0.38 – 1.07) 0.08 0.64 (0.37 – 1.10) 0.10
Caucasians 0.77 (0.38 – 1.53) 0.46 0.78 (0.39 – 1.57) 0.50
Afro-Caribbean 0.49 (0.18 – 1.28) 0.14 0.49 (0.18 – 1.31) 0.15
Asians 0.86 (0.07 – 10.42) 0.91 0.80 (0.06 – 10.0) 0.86
Recessive
Asp/Asp vs (Glu/Asp+Glu/Glu)
All women 0.74 (0.28 – 1.98) 0.65 0.83 (0.30 – 2.25) 0.70
Caucasians 0.99 (0.35 – 2.79) 0.99 0.95 (0.34 – 2.69) 0.95
Afro-Caribbean N.A   N.A  
Asians N.A   N.A  
Dominant
(Asp/Asp+Glu/Asp) vs Glu/Glu
All women 0.63 (0.39 – 1.04) 0.07 0.65 (0.39 – 1.08) 0.09
Caucasians 0.79 (0.42 – 1.51) 0.49 0.80 (0.42 – 1.53) 0.51
Afro-Caribbean 0.46 (0.17 – 1.21) 0.11 0.45 (0.17 – 1.22) 0.11
Asians 0.52 (0.05 – 5.62) 0.59 0.51 (0.04 – 5.68) 0.58
  1. *; ORs adjusted by maternal age, ethnic background and smoking status. In the comparisons of the eNOS genotype, the reference value for each comparison was set to 1.0. N.A; There were no women homozygous for the Asp-allele in the Afro-Caribbean or Asian ethnic group.