Endothelial nitric oxide synthase gene polymorphism (Glu298Asp) and development of pre-eclampsia: a case-control study and a meta-analysis

Table 2 Estimate of the effect of the eNOS Glu298Asp polymorphism on pre-eclampsia risk in the current case-control study stratified by ethnic group.

Model of inheritance	Unadjusted OR (95%CI)	P	Adjusted OR* (95%CI)	P
Additive
*Asp/Asp vs Glu/Glu*
All women	0.63 (0.23 – 1.72)	0.37	0.69 (0.25 – 1.92)	0.47
Caucasians	0.89 (0.30 – 2.59)	0.83	0.86 (0.29 – 2.52)	0.79
Afro-Caribbean	N.A		N.A
Asians	N.A		N.A
*Glu/Asp vs Glu/Glu*
	0.64 (0.38 – 1.07)	0.08	0.64 (0.37 – 1.10)	0.10
Caucasians	0.77 (0.38 – 1.53)	0.46	0.78 (0.39 – 1.57)	0.50
Afro-Caribbean	0.49 (0.18 – 1.28)	0.14	0.49 (0.18 – 1.31)	0.15
Asians	0.86 (0.07 – 10.42)	0.91	0.80 (0.06 – 10.0)	0.86
Recessive
*Asp/Asp vs (Glu/Asp+Glu/Glu)*
All women	0.74 (0.28 – 1.98)	0.65	0.83 (0.30 – 2.25)	0.70
Caucasians	0.99 (0.35 – 2.79)	0.99	0.95 (0.34 – 2.69)	0.95
Afro-Caribbean	N.A		N.A
Asians	N.A		N.A
Dominant
*(Asp/Asp+Glu/Asp) vs Glu/Glu*
All women	0.63 (0.39 – 1.04)	0.07	0.65 (0.39 – 1.08)	0.09
Caucasians	0.79 (0.42 – 1.51)	0.49	0.80 (0.42 – 1.53)	0.51
Afro-Caribbean	0.46 (0.17 – 1.21)	0.11	0.45 (0.17 – 1.22)	0.11
Asians	0.52 (0.05 – 5.62)	0.59	0.51 (0.04 – 5.68)	0.58

*; ORs adjusted by maternal age, ethnic background and smoking status. In the comparisons of the eNOS genotype, the reference value for each comparison was set to 1.0. N.A; There were no women homozygous for the Asp-allele in the Afro-Caribbean or Asian ethnic group.

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