|
Model of inheritance
|
Unadjusted OR (95%CI)
|
P
|
Adjusted OR* (95%CI)
|
P
|
|---|
|
Additive
|
|
Asp/Asp vs Glu/Glu
|
|
All women
|
0.63 (0.23 – 1.72)
|
0.37
|
0.69 (0.25 – 1.92)
|
0.47
|
|
Caucasians
|
0.89 (0.30 – 2.59)
|
0.83
|
0.86 (0.29 – 2.52)
|
0.79
|
|
Afro-Caribbean
|
N.A
| |
N.A
| |
|
Asians
|
N.A
| |
N.A
| |
|
Glu/Asp vs Glu/Glu
|
| |
0.64 (0.38 – 1.07)
|
0.08
|
0.64 (0.37 – 1.10)
|
0.10
|
|
Caucasians
|
0.77 (0.38 – 1.53)
|
0.46
|
0.78 (0.39 – 1.57)
|
0.50
|
|
Afro-Caribbean
|
0.49 (0.18 – 1.28)
|
0.14
|
0.49 (0.18 – 1.31)
|
0.15
|
|
Asians
|
0.86 (0.07 – 10.42)
|
0.91
|
0.80 (0.06 – 10.0)
|
0.86
|
|
Recessive
|
|
Asp/Asp vs (Glu/Asp+Glu/Glu)
|
|
All women
|
0.74 (0.28 – 1.98)
|
0.65
|
0.83 (0.30 – 2.25)
|
0.70
|
|
Caucasians
|
0.99 (0.35 – 2.79)
|
0.99
|
0.95 (0.34 – 2.69)
|
0.95
|
|
Afro-Caribbean
|
N.A
| |
N.A
| |
|
Asians
|
N.A
| |
N.A
| |
|
Dominant
|
|
(Asp/Asp+Glu/Asp) vs Glu/Glu
|
|
All women
|
0.63 (0.39 – 1.04)
|
0.07
|
0.65 (0.39 – 1.08)
|
0.09
|
|
Caucasians
|
0.79 (0.42 – 1.51)
|
0.49
|
0.80 (0.42 – 1.53)
|
0.51
|
|
Afro-Caribbean
|
0.46 (0.17 – 1.21)
|
0.11
|
0.45 (0.17 – 1.22)
|
0.11
|
|
Asians
|
0.52 (0.05 – 5.62)
|
0.59
|
0.51 (0.04 – 5.68)
|
0.58
|
- *; ORs adjusted by maternal age, ethnic background and smoking status. In the comparisons of the eNOS genotype, the reference value for each comparison was set to 1.0. N.A; There were no women homozygous for the Asp-allele in the Afro-Caribbean or Asian ethnic group.
