Table 2 Key definitions for outcome measures
Main outcomes | Definition |
|---|---|
pre-eclampsia | as defined in Table 1 |
pregnancy loss / neonatal death | miscarriage, fetal death or death of a liveborn infant before hospital discharge |
pre-term birth | pre-term birth: ≤ 37 weeks + 6 days of gestation moderately pre-term birth: ≤ 33 weeks + 6 days of gestation extremely pre-term birth: ≤ 27 weeks + 6 days of gestation |
small for gestational age (SGA) infant | infant with birth-weight below the 3rd centile, or as defined in the individual trial |
pregnancy with serious adverse outcome | pregnancy with any of the above main outcomes for the woman or any fetus/baby, or the death of the woman. If sufficient data available, severe maternal morbidity will also be included in this definition. |
Other outcomes | Definition |
early onset pre-eclampsia | as defined in Table 1 |
maternal death | death during pregnancy or up to 42 days after termination of the pregnancy |
antepartum haemorrhage | any vaginal bleeding before the onset of labour |
placental abruption | clear evidence of placental separation |
severe maternal morbidity | including eclampsia, HELLP syndrome, DIC, pulmonary oedema, liver failure, renal failure or CVA/stroke |
infant death | live born and any reported death from 29 days to 1 year of life or after hospital discharge |
neonatal bleeding | abnormal bleeding in the neonatal period including periventricular haemorrhage, gastrointestinal, umbilical or other sites |