Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study

Table 2 Genes, alleles, haplotypes and genotypes in women with preterm birth before 35 weeks and chorioamnionitis.

Gene	Histologic Chorio-amnionitis n = 69	No Histologic Chorio-amnionitis n = 112	Univariate analysis OR (95% CI) Uncorrected P value	Multivariable analysis OR (95% CI), P value
*IL10*
Allele-819 T	34 (0.50)	37 (0.33)	2.0 (1.0–3.8), 0.03
-592 A	34 (0.50)	37 (0.33)	2.0 (1.0–3.8), 0.03
Haplotype
-1082A/-819T/-592A	34 (0.49)	37 (0.33)	2.0 (1.0–3.8), 0.03	1.8 (1.0–4.0), 0.05
Genotype
-819 C/T	28 (0.41)	28 (0.25)	2.1 (1.0–4-1), 0.03
-592 A/C	28 (0.41)	28 (0.25)	2.1 (1.0–4-1), 0.03
*MBL2*
Codon 54Asp ('B')	27 (0.39)	28 (0.25)	1.9 (1.0–3.9), 0.04	2.0 (1.0–4.0), 0.04
*TNFRSF6*
Allele-1377A	9 (0.13)	30 (0.27)	0.4 (0.2–1.0), 0.03
Haplotype
-1377A/-670G	9 (0.13)	30 (0.27)	0.4 (0.2–1.0), 0.03	0.3 (0.2–0.9), 0.03
Genotype
-1377 G/G	60 (0.87)	82 (0.73)	2.4 (1.0–6.3), 0.03
*TGFB1*
Haplotype
-800G/-509T	2 (0.03)	14 (0.13)	0.2 (0.02–1.0), 0 .03	0.2 (0.04–0.9), 0.04
Homozygosity

Data are presented as number and frequencies of alleles, genotypes and haplotypes.
Univariate analyses were tested using Chi square analysis of 2 × 2 table, and uncorrected P values, Odds Ratio (OR), and 95% Confidence Intervals (CI), P values ≤ 0.07 are presented.
Multivariable analyses included genetic variables with P values ≤ 0.15 using backward step multiple logistic regression. Multivariable model included carriage of IL10 ATA, MBL2 codon 54Asp, TNFRS6-1377A/-670G (AG) haplotype, and homozygous TGFB1-800G/-509T, TNF +488 G/A, and IL1R1 +970 T/T genotypes.
MBL2 codon 54Asp (allele 'B') is a single nucleotide polymorphism in exon 1 codon 54 (Gly/Asp).
TNFRSF6 is the gene symbol for Fas; ns, not significant.

ISSN: 1471-2393