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Table 2 Genes, alleles, haplotypes and genotypes in women with preterm birth before 35 weeks and chorioamnionitis.

From: Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study

Gene Histologic Chorio-amnionitis n = 69 No Histologic Chorio-amnionitis n = 112 Univariate analysis OR (95% CI) Uncorrected P value Multivariable analysis OR (95% CI), P value
IL10     
Allele-819 T 34 (0.50) 37 (0.33) 2.0 (1.0–3.8), 0.03  
-592 A 34 (0.50) 37 (0.33) 2.0 (1.0–3.8), 0.03  
Haplotype     
-1082A/-819T/-592A 34 (0.49) 37 (0.33) 2.0 (1.0–3.8), 0.03 1.8 (1.0–4.0), 0.05
Genotype     
-819 C/T 28 (0.41) 28 (0.25) 2.1 (1.0–4-1), 0.03  
-592 A/C 28 (0.41) 28 (0.25) 2.1 (1.0–4-1), 0.03  
MBL2     
Codon 54Asp ('B') 27 (0.39) 28 (0.25) 1.9 (1.0–3.9), 0.04 2.0 (1.0–4.0), 0.04
TNFRSF6     
Allele-1377A 9 (0.13) 30 (0.27) 0.4 (0.2–1.0), 0.03  
Haplotype     
-1377A/-670G 9 (0.13) 30 (0.27) 0.4 (0.2–1.0), 0.03 0.3 (0.2–0.9), 0.03
Genotype     
-1377 G/G 60 (0.87) 82 (0.73) 2.4 (1.0–6.3), 0.03  
TGFB1     
Haplotype     
-800G/-509T 2 (0.03) 14 (0.13) 0.2 (0.02–1.0), 0 .03 0.2 (0.04–0.9), 0.04
Homozygosity     
  1. Data are presented as number and frequencies of alleles, genotypes and haplotypes.
  2. Univariate analyses were tested using Chi square analysis of 2 × 2 table, and uncorrected P values, Odds Ratio (OR), and 95% Confidence Intervals (CI), P values ≤ 0.07 are presented.
  3. Multivariable analyses included genetic variables with P values ≤ 0.15 using backward step multiple logistic regression. Multivariable model included carriage of IL10 ATA, MBL2 codon 54Asp, TNFRS6-1377A/-670G (AG) haplotype, and homozygous TGFB1-800G/-509T, TNF +488 G/A, and IL1R1 +970 T/T genotypes.
  4. MBL2 codon 54Asp (allele 'B') is a single nucleotide polymorphism in exon 1 codon 54 (Gly/Asp).
  5. TNFRSF6 is the gene symbol for Fas; ns, not significant.