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Table 1 Demographic and clinical characteristics of women with preterm birth before 35 weeks.

From: Polymorphisms in immunoregulatory genes and the risk of histologic chorioamnionitis in Caucasoid women: a case control study

Variable

Histologic Chorio-amnionitis n = 69

No Histologic Chorio-amnionitis n = 112

Significant OR (95% CI), and Uncorrected P values

Maternal age (years)

29 (16–41)

30 (17–44)

 

Delivery gestation (weeks)

28 (20–34)

30 (23–34)

*

Mean birth weight

1399 (± 676)

1897 (± 504)

< 0.0001

Maternal age ≥ 35 years

11 (16%)

18 (16%)

ns

Maternal age ≤ 17 years

2 (3%)

2 (2%)

ns

Any smoking

22 (31%)

29 (26%)

ns

Any alcohol

44 (64%)

73 (65%)

ns

Any substance use

7 (10%)

10 (9%)

ns

Partner change for

14 (20%)

20 (18%)

ns

pregnancy

   

Cervical cerclage

3 (4%)

2 (2%)

ns

Previous mid-trimester

4 (6%)

12 (11%)

ns

miscarriage (12–20 weeks)

   

2 or more preterm births

11 (16%)

20 (18%)

ns

Placenta praevia after 22 weeks with bleeding

1 (1%)

2 (2%)

ns

Documented clinical chorioamnionitis

22 (32%)

8 (7%)

6.1 (2.4–17), < 0.001

PPROM ≥ 3 hours

39 (57%)

74 (66%)

ns

Gestation < 29 weeks

33 (48%)

12 (11%)

7.6 (3.4–18), < 0.001

Documented positive

   

placental culture

10 (14%)

6 (5%)

3.0 (0.9–11), 0.04

Neonatal sepsis

10 (14%)

0

19 (3 – 823), < 0.001

Neonatal death

6 (9%)

3 (3%)

ns

Post partum endometritis

5 (7%)

3 (3%)

ns

  1. Descriptive statistical results are mean (± SD) or number (%) as appropriate, and maternal age and gestation as median (range). Characteristics are from index birth. PPROM = Preterm premature rupture of membranes 3 hours or more before delivery < 35 weeks.
  2. Univariate analyses were tested using Chi square analysis of 2 × 2 table, and uncorrected P values, Odds Ratio (OR), and 95% Confidence Intervals (CI), P values ≤ 0.05 are presented. Mean birth weights were tested by two-sample t-test, assuming unequal variances.
  3. * See Figure 1,
  4. ns, not significant.