Table 2 Frequency of alleles at 26 single nucleotide polymorphisms in the promoter and coding region of pituitary growth hormone and the nucleotide present at the homologous site in other members of the human GH locus

-580

A

0.985

A

A

A

A

Constant

G

0.015

-476

A

0.012

0.013

A

G

A

G

Variant

G

0.988

0.987

-360

A

0.972

G

G

G

G

Variant

G

0.028

-352

G

0.012

T

G

G

G

Variant

T

0.988

-308

G

0.732

0.753

T

C

T

C

Variant

T

0.268

0.247

-301

G

0.732

0.753

T

T

T

T

Variant

T

0.268

0.247

-278

G

0.628

0.601

T

A

T

A

Variant

NF1

T

0.372

0.399

-168

C

0.024

0.019

T

C

T

C

Variant

T

0.976

0.981

-75

A

0.900

0.886

G

A

G

A

Variant

PIT-1

G

0.100

0.114

-57

G

0.687

0.633

G

T

A

T

Variant

Vitamin D Receptor

T

0.313

0.367

-31

G

0.882

0.867

G

G

-

G

Variant

Vitamin D Receptor

-

0.118

0.133

-6

A

0.565

0.588

A

G

A

G

Variant

Transcription Start

G

0.435

0.412

-1

A

0.847

0.932

C

T

A

T

Variant

Transcription Start

C

0.044

0.003

T

0.109

0.065

3

C

0.044

0.003

C

G

G

G

Variant

Transcription Start

G

0.956

0.997

16

A

0.976

0.981

G

A

A

A

Variant

5' UTR

G

0.024

0.019

25

A

0.980

0.981

C

A

A

A

Variant

5' UTR

C

0.020

0.019

59

G

0.072

0.049

G

G

G

G

Variant

5' UTR

T

0.928

0.951

69

A

0.968

G

C

G

G

Variant

Thr/Ala

G

0.032

124

A

0.988

G

A

G

A

Variant

Intron

G

0.012

128

A

0.988

C

C

T

C

Variant

Intron

T

0.012

140

A

0.004

G

G

G

G

Constant

Intron

G

0.996

144

A

0.012

G

G

G

G

Constant

Intron

G

0.988

281

C

0.024

T

C

C

C

Variant

Intron

T

0.976

596

C

0.986

T

T

T

T

Variant

Intron

T

0.014

1070

A

0.004

G

G

G

G

Constant

Synonymous

G

0.996

1169

A

0.331

T

T

T

T

Constant

Intron

T

0.669