Table 1 Sample sizes for a range of power calculations for the composite primary outcome
25% reduction in risk of death or neurosensory disability | ||||
|---|---|---|---|---|
18%→13.5% | 20%→15% | 22%→16.5% | 24%→18% | |
alpha 0.05, power 90% | 2840 | 2500 | 2230 | 2000 |
alpha 0.05, power 80% | 2140 | 1890 | 1684 | 1512 |
20% reduction in risk of death or neurosensory disability | ||||
18%→14.4% | 20%→16% | 22%→17.6% | 24%→19.2% | |
alpha 0.05, power 80% | 3390 | 2990 | 2664 | 2390 |
alpha 0.05, power 70% | 2376 | 2114 | 2114 | 1896 |
15% reduction in risk of death or neurosensory disability | ||||
18%→15.3% | 20%→17% | 22%→18.7% | 24%→20.4% | |
alpha 0.05, power 60% | 3870 | 3410 | 3036 | 2722 |