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Table 4 Laboratory data (geometric mean and 95% confidence interval) for senior participants (age 65 years or over) between Phase I and Phase II

From: A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects

Characteristic Phase I Phase II P value
Total participants (n) 202 186  
   Serum folate (nmol/L) 14.8 (14.0 – 15.6) 23.0 (22.0 – 24.1) <0.001
   RBC folate (mol/L) 745 (713 – 779) 916 (873 – 961) <0.001
   Plasma HCY (μmol/L) 13.6 (13.0 – 14.2) 12.3 (11.7 – 12.9) 0.001
   Serum vitamin B12 (pmol/L) 183 (173 – 194) 216 (202 – 231) <0.001
   Plasma MMA (μmol/L) 0.24 (0.22 – 0.27) 0.26 (0.24 – 0.28) 0.229
  1. † The Komogorov-Smirnov test showed that the log transformed data were non-normal (p < 0.05).
  2. ‡ P value for the difference between Phase I and Phase II is based on a non-parametric Mann-Whitney U test.
  3. RBC denotes red blood cell, HCY denotes homocysteine and MMA refers to methylmalonic acid.