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Table 1 Framework for a two phase, multi site study to examine the effects of food fortification with folic acid

From: A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects

Content Study objective Sample ** Location
I. Rates of NTDs Determine rate of NTD-affected pregnancies, pre and post fortification Newfoundland population Newfoundland
II. Dietary assessment* Determine dietary intake of folate, pre and post Fortification A) Non-pregnant women of childbearing age (19–44 years), not taking supplements containing folic acid; St. John's, Rural Newfoundland
III. Blood analysis* Determine blood folate and vitamin B12 status, pre and post fortification B) Seniors (65 years or older) not taking supplements containing folic acid or B12 supplement and not diagnosed with anaemia. St. John's, Rural Newfoundland
IV. Knowledge and intake of folic acid supplements Determine knowledge and consumption of folic acid supplements, pre and post fortification Non-pregnant women of childbearing age (19–44 years) St. John's, Rural Newfoundland
  1. * The same sample of women and seniors are analyzed in Components II and III.
  2. ** Sampling was done separately for Phases I and II.