From: Is in vitro fertilization associated with preeclampsia? A propensity score matched study
Eligible study sample (n = 3084) | Propensity score matched sample (n = 948) | ||||||
---|---|---|---|---|---|---|---|
IVF group (n = 474) | Non-IVF group (n = 2610) | P value | IVF group (n = 474) | Non-IVF group (n = 474) | P value | ||
Maternal demographics | |||||||
Age | Year, mean (SD) | 38.3 (3.3) | 34.8 (4.2) | <0.001 | 38.3 (3.3) | 38.4 (3.3) | 0.97 |
Age at marriage | Year, mean (SD) | 30.8 (4.1) | 29.3 (3.8) | <0.001 | 30.8 (4.1) | 31.0 (4.1) | 0.91 |
Parity | 0, n (%) | 370 (78.1) | 1319 (50.5) | <0.001 | 370 (78.1) | 378 (79.8) | 0.74 |
≥1, n (%) | 104 (21.9) | 1291 (49.5) | 104 (21.9) | 96 (20.3) | |||
Abortion | 0, n (%) | 291 (61.4) | 1767 (67.7) | 0.009 | 291 (61.4) | 304 (64.1) | 0.39 |
1-2, n (%) | 152 (32.1) | 734 (28.1) | 152 (32.1) | 136 (28.7) | |||
3≤, n (%) | 31 (6.5) | 109 (4.2) | 31 (6.5) | 34 (7.2) | |||
Work | Homemaker, n (%) | 189 (39.9) | 1122 (43.0) | 0.31 | 189 (39.9) | 190 (40.1) | 0.93 |
Full time, n (%) | 248 (52.3) | 1268 (48.6) | 248 (52.3) | 238 (50.2) | |||
Part time, n (%) | 36 (7.6) | 200 (7.7) | 36 (7.6) | 45 (9.5) | |||
Missing, n (%) | 1 (0.2) | 20 (0.8) | 1 (0.2) | 1 (0.2) | |||
Maternal health status | |||||||
Height | cm, mean (SD) | 160.0 (5.4) | 159.4 (5.2) | 0.015 | 160.0 (5.4) | 159.8 (5.1) | 0.75 |
Weight before pregnancy | kg, mean (SD) | 52.4 (6.9) | 51.5 (7.8) | 0.011 | 52.4 (6.9) | 52.0 (7.2) | 0.74 |
Smoking during pregnancy | Yes, n (%) | 6 (1.3) | 92 (3.5) | 0.01 | 6 (1.3) | 6 (1.3) | 0.27 |
Drinking during pregnancy | Yes, n (%) | 0 (0) | 11 (0.4) | 0.39 | 0 (0) | 0 (0) | NA |
Family history of hypertension | Yes, n (%) | 110 (23.2) | 414 (15.9) | <0.001 | 110 (23.2) | 104 (21.9) | 0.82 |
Systolic blood pressure <20 weeks of gestation | mmHg, mean (SD) | 110.4 (10.4) | 108.4 (10.2) | <0.001 | 110.4 (10.4) | 110.9 (9.9) | 0.75 |
Diastolic blood pressure <20 weeks of gestation | mmHg, mean (SD) | 64.8 (7.3) | 62.8 (7.1) | <0.001 | 64.8 (7.3) | 65.0 (7.0) | 0.86 |
Maternal medical complication | |||||||
Central nervous system disease | Yes, n (%) | 0 (0) | 27 (1.0) | 0.016 | 0 (0) | 1 (0.2) | >0.99 |
Cerebrovascular disease | Yes, n (%) | 0 (0) | 4 (0.2) | >0.99 | 0 (0) | 1 (0.2) | >0.99 |
Asthma | Yes, n (%) | 13 (2.7) | 92 (3.5) | 0.49 | 13 (2.7) | 9 (1.9) | 0.29 |
Respiratory disease (except asthma) | Yes, n (%) | 2 (0.4) | 3 (0.1) | 0.17 | 2 (0.4) | 4 (0.8) | >0.99 |
Gastrointestinal disease | Yes, n (%) | 2 (0.4) | 33 (1.3) | 0.15 | 2 (0.4) | 1 (0.2) | 0.57 |
Liver disease | Yes, n (%) | 3 (0.6) | 16 (0.6) | >0.99 | 3 (0.6) | 2 (0.4) | 0.57 |
Hematologic disease | Yes, n (%) | 2 (0.4) | 16 (0.6) | >0.99 | 2 (0.4) | 2 (0.4) | >0.99 |
Cardiovascular disease | Yes, n (%) | 5 (1.1) | 51 (2.0) | 0.26 | 5 (1.1) | 4 (0.8) | 0.42 |
Hyperthyroidism | Yes, n (%) | 7 (1.5) | 47 (1.8) | 0.85 | 7 (1.5) | 4 (0.8) | >0.99 |
Hypothyroidism | Yes, n (%) | 13 (2.7) | 70 (2.7) | 0.88 | 13 (2.7) | 14 (3.0) | 0.29 |
Psychiatric disease | Yes, n (%) | 10 (2.1) | 64 (2.5) | 0.75 | 10 (2.1) | 9 (1.9) | >0.99 |
Autoimmune disease | Yes, n (%) | 9 (1.9) | 55 (2.1) | 0.86 | 9 (1.9) | 6 (1.3) | >0.99 |
Pre-existing diabetes mellitus | Yes, n (%) | 1 (0.2) | 15 (0.6) | 0.49 | 1 (0.2) | 2 (0.4) | 0.57 |
Paternal demographics | |||||||
Age | Year, mean (SD) | 40.8 (4.8) | 37.3 (4.9) | <0.001 | 40.8 (4.8) | 40.6 (4.8) | 0.25 |
Age at marriage | Year, mean (SD) | 33.3 (5.3) | 31.7 (4.8) | <0.001 | 33.3 (5.3) | 33.2 (5.6) | 0.37 |
Paternal health status | |||||||
Partner's smoking status | Yes, n (%) | 136 (28.7) | 705 (27.0) | 0.31 | 136 (28.7) | 140 (29.5) | 0.84 |
Missing, n (%) | 6 (1.3) | 59 (2.3) | 6 (1.3) | 6 (1.3) | |||
Partner's height | cm, mean (SD) | 172.7 (5.8) | 173.1 (5.7) | 0.16 | 172.7 (5.8) | 173.4 (5.6) | 0.10 |
Partner's weight | kg, mean (SD) | 69.6 (9.2) | 69.8 (9.6) | 0.70 | 69.6 (9.2) | 70.1 (9.0) | 0.64 |