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Table 3 Univariate ROC curve analysis for each marker and the detection rate (DR) for preeclampsia at a fixed false-positive rate (FPR) of 10% and 5%

From: Screening models using multiple markers for early detection of late-onset preeclampsia in low-risk pregnancy

Variable Cutoff1 DR1 Cutoff2 DR2 Area SE p-value 95% CI
BMI, kg/m2 23.6 37.5 24.3 25 0.769 0.086 0.010 0.600 0.937
PAPP-A, MoM 0.58 50 0.49 50 0.707 0.116 0.046 0.480 0.935
Inhibin A, MoM 1.76 50 2.18 50 0.780 0.095 0.007 0.593 0.967
sFlt-11, (pg/ml) 2358 75 3064 25 0.842 0.080 0.001 0.686 0.998
sFlt-12 4680 75 6040 50 0.944 0.020 <0.001 0.906 0.983
PlGF1, (pg/ml) 257 62.5 200 37.5 0.751 0.103 0.016 0.549 0.953
PlGF2 113.4 50 86.5 37.5 0.847 0.060 0.001 0.729 0.965
sFlt-1/PlGF1 6.05 75 7.0 75 0.851 0.092 0.001 0.670 1.000
sFlt-1/PlGF2 28.2 87.5 43.7 50 0.939 0.033 <0.001 0.873 1.000
  1. Cutoff1: cutoff value at a fixed FPR of 10%, DR1: DR at a fixed FPR of 10%, Cutoff2: cutoff value at a fixed FPR of 5%, DR2: DR at a fixed FPR of 5%, PAPP-A: pregnancy-associated plasma protein-A, sFlt-11: second trimester sFlt-1, PlGF1: second trimester PlGF, sFlt-1/PlGF1: second trimester sFlt-1/PlGF ratio, sFlt-12: third trimester sFlt-1, PlGF2: third trimester PlGF, sFlt-1/PlGF2: third trimester sFlt-1/PlGF ratio, SE: standard error.