Screening models using multiple markers for early detection of late-onset preeclampsia in low-risk pregnancy

Table 3 Univariate ROC curve analysis for each marker and the detection rate (DR) for preeclampsia at a fixed false-positive rate (FPR) of 10% and 5%

Variable	Cutoff¹	DR¹	Cutoff²	DR²	Area	SE	p-value	95% CI
BMI, kg/m²	23.6	37.5	24.3	25	0.769	0.086	0.010	0.600	0.937
PAPP-A, MoM	0.58	50	0.49	50	0.707	0.116	0.046	0.480	0.935
Inhibin A, MoM	1.76	50	2.18	50	0.780	0.095	0.007	0.593	0.967
sFlt-1¹, (pg/ml)	2358	75	3064	25	0.842	0.080	0.001	0.686	0.998
sFlt-1²	4680	75	6040	50	0.944	0.020	<0.001	0.906	0.983
PlGF¹, (pg/ml)	257	62.5	200	37.5	0.751	0.103	0.016	0.549	0.953
PlGF²	113.4	50	86.5	37.5	0.847	0.060	0.001	0.729	0.965
sFlt-1/PlGF¹	6.05	75	7.0	75	0.851	0.092	0.001	0.670	1.000
sFlt-1/PlGF²	28.2	87.5	43.7	50	0.939	0.033	<0.001	0.873	1.000

Cutoff¹: cutoff value at a fixed FPR of 10%, DR¹: DR at a fixed FPR of 10%, Cutoff²: cutoff value at a fixed FPR of 5%, DR²: DR at a fixed FPR of 5%, PAPP-A: pregnancy-associated plasma protein-A, sFlt-1¹: second trimester sFlt-1, PlGF¹: second trimester PlGF, sFlt-1/PlGF¹: second trimester sFlt-1/PlGF ratio, sFlt-1²: third trimester sFlt-1, PlGF²: third trimester PlGF, sFlt-1/PlGF²: third trimester sFlt-1/PlGF ratio, SE: standard error.

ISSN: 1471-2393