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Table 3 Risk difference of severe congenital heart defects between exposed and unexposed stratified by socioeconomic groups

From: Increased risk of severe congenital heart defects in offspring exposed to selective serotonin-reuptake inhibitors in early pregnancy – an epidemiological study using validated EUROCAT data

 

Severe CHD (n = 129)

 

n (%)

ARD¤per 1,000 exposed to SSRIs (95% CI)

Marital status

  

Single

25 (19.38)

1.17 (-5.71; 8.06)

Cohabiting

52 (40.31)

7.19 (-3.00; 17.37)

Married

52 (40.31)

5.71 (-4.66; 16.07)

Maternal educational level

  

Basic

40 (31.01)

8.42 (-4.79; 21.63)

Intermediate

53 (41.09)

4.00 (-3.49; 11.49)

Higher

36 (27.91)

3.21 (-5.76; 12.18)

Maternal income group

  

Low

24 (18.60)

2.90 (-6.83; 12.63)

Below average + average

55 (42.64)

4.53 (-2.93; 12.00)

Above average + high

50 (38.76)

6.80 (-4.96; 18.56)

  1. SSRI, selective serotonin-reuptake inhibitor. CHD, congenital heart defects. ARD, adjusted risk difference. Estimates are presented as ARD with 95% confidence intervals (95% CIs).
  2. ¤Multivariable Binomial Regressions are adjusted for maternal age, year of conception, and use of antiepileptics and/or insulin during first trimester. Categories of maternal income group are combined in order to ensure, that all categories contain exposed cases. No exposed cases had other origin than Danish, why estimates could not be stratified in relation to country of origin.
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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