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Table 1 Characteristics of exposed to SSRIs versus unexposed

From: Increased risk of severe congenital heart defects in offspring exposed to selective serotonin-reuptake inhibitors in early pregnancy – an epidemiological study using validated EUROCAT data

Characteristics

Unexposed (n = 71435) n (%)

Exposed to any SSRI (n = 845) n (%)

p value*

Year of conception

   

1995-1997

16793 (23.51)

54 (6.39)

<0.001

1998-2001

21845 (30.58)

145 (17.16)

 

2002-2004

15647 (21.90)

212 (25.09)

 

2005-2008

17150 (24.01)

434 (51.36)

 

Missing

0 (-)

0 (-)

 

Educational level

   

Basic

12279 (17.19)

251 (29.70)

<0.001

Intermediate

34016 (47.62)

370 (43.79)

 

Higher

25140 (35.19)

224 (26.51)

 

Missing

0 (-)

0 (-)

 

Income group

   

Low

11715 (16.40)

175 (20.71)

<0.001

Below average

14840 (20.77)

250 (29.59)

 

Average

15148 (21.21)

188 (22.25)

 

Above average

15100 (21.14)

125 (14.79)

 

High

14632 (20.48)

107 (12.66)

 

Missing

0 (-)

0 (-)

 

Country of origin

   

Danish

64355 (90.09)

772 (91.36)

0.337

Other Western

1818 (2.54)

22 (2.60)

 

Non-Western

5262 (7.37)

51 (6.04)

 

Missing

0 (-)

0 (-)

 

Marital status

   

Single

11701 (16.38)

254 (30.06)

<0.001

Cohabiting

30812 (43.13)

328 (38.82)

 

Married

28922 (40.49)

263 (31.12)

 

Missing

0 (-)

0 (-)

 

Maternal age

   

≤ 24 years

13110 (18.35)

172 (20.36)

<0.001

25-29 years

27506 (38.50)

291 (34.44)

 

30-34 years

22303 (31.22)

236 (27.93)

 

35-39 years

7507 (10.51)

120 (14.20)

 

≥ 40 years

1009 (1.41)

26 (3.08)

 

Missing

0 (-)

0 (-)

 

Smoking during pregnancy

   

Yes

13182 (18.45)

271 (32.07)

<0.001

No

51537 (72.15)

511 (60.47)

 

Missing

6716 (9.40)

63 (7.46)

 

Use of antiepileptics and/or insulin during pregnancy

   

Yes

782 (1.09)

27 (3.20)

<0.001

No

70653 (98.91)

818 (96.80)

 

Missing

0 (-)

0 (-)

 
  1. SSRI, selective serotonin-reuptake inhibitor. *χ2 test were used to calculate the overall p value for comparison of pregnancies exposed to SSRIs in first trimester with unexposed. Information on smoking during pregnancy and multiple pregnancies were only available for live- and stillbirths.