Mortality and major morbidities in very preterm infants born from assisted conception or naturally conceived: results of the area-based ACTION study

Table 3 Adjusted odds ratios (aOR) of neonatal morbidity and mortality outcomes comparing AC and non-AC babies, separately for singletons and multiples

	Singletons		Multiples
	aOR¹	95% CI	aOR¹	95% CI
PDA	1.63	0.84-3.16	0.64	0.45-0.90
IVH, grade 3-4	2.40	0.93-6.19	1.08	0.52-2.23
c-PVL	- ²	-	1.09	0.46-2.58
IVH grade 3-4 or c-PVL	1.36	0.59-3.14	1.00	0.55-1.81
Sepsis/meningitis	0.48	0.20-1.17	0.89	0.53-1.47
NEC	- ²	-	0.44	0.19-1.02
ROP, stage ≥3	0.57	0.06-5.51	0.36	0.11-1.15
BPD	1.37	0.58-3.23	0.41	0.20-0.87
Death before discharge	1.60	0.72-3.54	0.79	0.47-1.33
Survival without major morbidities	0.75	0.43-1.30	1.30	0.85-1.99

PDA: Patent ductus arteriosus; IVH: Intraventricular haemorrhage; c-PVL: Cystic periventricular leukomalacia; NEC: Necrotizing enterocolitis; ROP: Retinopathy of prematurity; BPD: Bronchopulmonary dysplasia.
¹aORs indicate the association between AC and outcomes, adjusting for gender, antenatal steroids, gestational age, SGA status (<10^th BW percentile), mode of delivery, region of birth, and mothers’ characteristics (age, country of origin, education, and previous births).
²No estimation of the aORs was possible because no cases of c-PVL and NEC were reported for AC singletons.

ISSN: 1471-2393