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Table 4 Results of receiver operating characteristic curve analysis with AUC values and cut-off levels of maternal serum PlGF (pg/mL) and sFLT-1 (pg/mL) levels and their ratio, resulting in optimal sensitivity and specificity

From: Prediction of preeclampsia and induced delivery at <34 weeks gestation by sFLT-1 and PlGF in patients with abnormal midtrimester uterine Doppler velocimetry: a prospective cohort analysis

  

AUC

Cut-off

Sensitivity

Specificity

PPV

NPV

PE (n = 12)

PlGF

0.697

133.8

75.0%

76.3%

50.0%

90.6%

 

sFLT-1

0.693

1171.5

91.7%

52.6%

37.9%

95.3%

 

sFLT-1/PlGF ratio

0.721

13.0

66.7%

86.8%

61.5%

89.2%

EO PE (n = 9)

sFLT-1/PlGF ratio

0.735

13.0

75.0%

83.3%

51.4%

93.4%

Gestational hypertension (n = 16)

PlGF

0.494

117.6

37.5%

70.6%

37.5%

70.6%

 

sFLT-1

0.364

590.5

100.0%

11.8%

34.8%

100.0%

 

sFLT-1/PlGF ratio

0.456

2.3

100.0%

8.8%

34.0%

100.0%

IUGR (n = 6)

PlGF

0.640

262.3

100.0%

38.6%

18.2%

100.0%

 

sFLT-1

0.439

1751.0

50.0%

63.6%

15.8%

90.3%

 

sFLT-1/PlGF ratio

0.564

8.0

66.7%

56.8%

17.4%

92.6%

Induced delivery < 34 weeks (n = 7)

PlGF

0.834

133.8

85.7%

72.1%

33.3%

96.9%

 

sFLT-1

0.807

1850.5

85.7%

74.4%

35.3%

97.0%

 

sFLT-1/PlGF ratio

0.877

13.0

85.7%

83.7%

46.1%

97.3%

  1. PE = Preeclampsia, EO = Early-onset, IUGR = Intrauterine growth restriction, ID = Induced delivery, PPV = positive predictive value, NPV = negative predictive value.